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Usage

Uses

Used in Organic Synthesis:
2-Methoxy-4-mercaptobenzoic acid is used as a key intermediate in the synthesis of various organic compounds. Its unique structure allows it to participate in a range of chemical reactions, making it a valuable building block for the development of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Methoxy-4-mercaptobenzoic acid is used as a precursor for the synthesis of therapeutic agents. Its ability to form stable derivatives and participate in various chemical reactions makes it a promising candidate for the development of new drugs with potential medicinal properties.
Used in Agrochemical Industry:
2-Methoxy-4-mercaptobenzoic acid is also utilized in the agrochemical industry for the synthesis of active ingredients in pesticides and other crop protection products. Its chemical versatility enables the creation of compounds with targeted pest control capabilities, contributing to more effective and sustainable agricultural practices.
Used in Specialty Chemicals:
In the specialty chemicals sector, 2-Methoxy-4-mercaptobenzoic acid is employed as a raw material for the production of various high-value compounds. Its unique structure and reactivity make it suitable for the development of dyes, fragrances, and other specialty chemicals that require specific functional groups and properties.

Upstream product

• 89469-32-9 4-Chlorosulphonyl-2-methoxybenzoic acid 
• 28478-45-7 methyl 4-benzyloxy-2-methoxybenzoate 
• 5427-29-2 methyl 2-hydroxy-4-benzyloxybenzoate 
• 7134-16-9 3-methoxy-4-methylbenzenesulfonic acid 
• 5428-54-6 2-methyl-5-nitrophenol 
• 13120-77-9 2-methyl-5-nitroanisole 
• 2597-56-0 4-nitro-o-anisic acid 
• 2486-80-8 4-amino-2-methoxybenzoic acid 
• 140-89-6 potassium ethyl xanthogenate 
• 97-06-3 4-methyl-3-nitro-benzenesulfonic acid 
• 7134-03-4 3-hydroxy-4-methylbenzenesulfonic acid 
• 618-03-1 3-amino-4-methylbenzenesulfonic acid 
• 136669-90-4 methyl 2-hydroxy-4-(trityloxy)benzoate 
• 89-86-1 4-hydroxysalicylic acid 

Downstream Products

• 114086-41-8 4-methanesulfonyl-2-methoxybenzoic acid 
• 136669-97-1 C-(2-Methoxy-4-methylsulfanyl-phenyl)-C-(4-methylsulfanyl-phenyl)-methylamine; compound with toluene-4-sulfonic acid 
• 136669-95-9 4-{2-[(9H-Fluoren-9-ylmethoxycarbonylamino)-(4-methanesulfinyl-phenyl)-methyl]-5-methanesulfinyl-phenoxy}-butyric acid 
• 136669-99-3 ({[(4-Methanesulfinyl-2-methoxy-phenyl)-(4-methanesulfinyl-phenyl)-methyl]-carbamoyl}-methyl)-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 136669-94-8 4-{2-[[(E)-Hydroxyimino]-(4-methylsulfanyl-phenyl)-methyl]-5-methylsulfanyl-phenoxy}-butyric acid 
• 144888-64-2 4-[5-Methylsulfanyl-2-(4-methylsulfanyl-benzoyl)-phenoxy]-butyric acid methyl ester 
• 136669-93-7 4-[5-Methylsulfanyl-2-(4-methylsulfanyl-benzoyl)-phenoxy]-butyric acid 
• 136669-92-6 (2-Methoxy-4-methylsulfanyl-phenyl)-(4-methylsulfanyl-phenyl)-methanone 
• 69883-78-9 2-methoxy-4-(methylthio)benzoyl chloride 
• 136063-68-8 Hexyl-(2-methoxy-4-propylsulfanyl-phenyl)-amine 
• 141410-91-5 2-Methoxy-4-(propane-1-sulfonyl)-phenylamine 
• 136063-56-4 Butyl-(2-methoxy-4-propylsulfanyl-phenyl)-amine 
• 136063-67-7 N-propyl-4-propylthio-o-anisidine 
• 136063-61-1 [2-Methoxy-4-(propane-1-sulfinyl)-phenyl]-methyl-amine 

Relevant academic research and scientific papers

Synthesis of 2-Methoxy-4-(methylsulfanyl)benzoic Acid — An Intermediate Product in the Preparation of the Cardiotonic Drugs Sulmazole and Isomazole

Readily available 4-methyl-3-nitrobenzenesulfonic acid and 2-methyl-5-nitrophenol were used to develop two alternative approaches to the synthesis of 2-methoxy-4-(methylsulfanyl)benzoic acid in total yields of 17% and 37%, respectively. The synthesis starting from 2-methyl-5-nitrophenol is more process-oriented and can be used in the resynthesis of Sulmazole and Isomazole.

Safety-catch anchoring linkage for synthesis of peptide amides by Boc/Fmoc strategy

2-Methoxy-4,4'-bis(methylthio)benhydrylamine (10) and the corresponding disulfoxide were prepared and tested as a model amide protecting groups for their stability toward acidic conditions. Subsequently, the novel 4-[4,4'-bis(methylsulfinyl)-2-oxy-(9-fluorenylmethyloxycarbonyl) benzhydrylamino]butanoic acid (SCAL) handle (9) has been prepared and applied to solid-phase peptide synthesis of C-terminal peptide amide using both 9-fluorenylmethyloxycarbonyl (Fmoc) and tert-butyloxycarbonyl (Boc) groups for N(α)-amino protection.

Structure-activity relationships of arylimidazopyridine cardiotonics: Discovery and inotropic activity of 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]pyridine

Recently several noncatecholamine, nonglycoside cardiotonic drugs have been discovered that possess both inotropic and vasodilator activities in experimental animals and man. Prototypical compounds include amrinone, sulmazole, and fenoximone. We investigated the structural requirements necessary for optimal inotropic activity in a series of molecules containing a heterocyclic ring fused to 2-phenylimidazole and discovered that 2-phenylimidazo[4,5-c]pyridines were generally 5-10-fold more potent than analogous 2-phenylimidazo[4,5-b]pyridines (e.g., sulmazole) or 8-phenylpurines. Furthermore, all imidazo[4,5-c]pyridine analogues we tested were orally active; in contrast, only one of the imidazo[4,5-b]pyridine derivatives, sulmazole, was significantly active. One of several highly active compounds in the [4,5-c] series was 50 (LY175326, 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H- imidazo[4,5-c]pyridine hydrochloride). The structure-activity relationship of this series is presented and compared to that of the imidazo[4,5-b]pyridine and purine series.