144888-64-2

Upstream product

• 4897-84-1 Methyl 4-bromobutyrate 
• 136669-91-5 2-hydroxy-4,4'-bis(methylthio)benzophenone 
• 136669-92-6 (2-Methoxy-4-methylsulfanyl-phenyl)-(4-methylsulfanyl-phenyl)-methanone 
• 28478-46-8 methyl 4-hydroxy-2-methoxybenzoate 
• 89-86-1 4-hydroxysalicylic acid 
• 2150-47-2 methyl 2,4-dihydroxybenzoate 
• 136669-90-4 methyl 2-hydroxy-4-(trityloxy)benzoate 
• 69883-78-9 2-methoxy-4-(methylthio)benzoyl chloride 
• 72856-73-6 2-methoxy-4-(methylsulfanyl)benzoic acid 
• 95420-72-7 4-mercapto-2-methoxybenzoic acid 
• 95420-30-7 4-<(dimethylamino)thioxomethoxy>-2-methoxybenzoic acid methyl ester 

Downstream Products

• 136669-93-7 4-[5-Methylsulfanyl-2-(4-methylsulfanyl-benzoyl)-phenoxy]-butyric acid 
• 136669-94-8 4-{2-[[(E)-Hydroxyimino]-(4-methylsulfanyl-phenyl)-methyl]-5-methylsulfanyl-phenoxy}-butyric acid 
• 136669-95-9 4-{2-[(9H-Fluoren-9-ylmethoxycarbonylamino)-(4-methanesulfinyl-phenyl)-methyl]-5-methanesulfinyl-phenoxy}-butyric acid 

Relevant academic research and scientific papers

Unusual KF/Al2O3 Promoted Tandem Electrophilic-Nucleophilic Aromatic Substitution Leading to the Xanthone Formation

Formation of xanthone (III) by the KF/Al2O3 mediated O-alkylation of 2-hydroxybenzophenone (I) is described and mechanistic rationalization is proposed for this unexpected side-reaction. Key words: O-alkylation, fluoride anion, xanthone

Safety-catch anchoring linkage for synthesis of peptide amides by Boc/Fmoc strategy

2-Methoxy-4,4'-bis(methylthio)benhydrylamine (10) and the corresponding disulfoxide were prepared and tested as a model amide protecting groups for their stability toward acidic conditions. Subsequently, the novel 4-[4,4'-bis(methylsulfinyl)-2-oxy-(9-fluorenylmethyloxycarbonyl) benzhydrylamino]butanoic acid (SCAL) handle (9) has been prepared and applied to solid-phase peptide synthesis of C-terminal peptide amide using both 9-fluorenylmethyloxycarbonyl (Fmoc) and tert-butyloxycarbonyl (Boc) groups for N(α)-amino protection.