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Usage

Uses

Used in Pharmaceutical Industry:
1-Phenylpropan-2-one is utilized as a precursor in the synthesis of various pharmaceuticals for its ability to be chemically modified to produce a range of medicinal compounds.
Used in Chemical Industry:
1-Phenylpropan-2-one is employed as a chemical intermediate in the production of other organic compounds, highlighting its versatility in chemical synthesis processes.
Used in Illicit Drug Manufacturing:
Regrettably, 1-Phenylpropan-2-one is also used in the illegal manufacture of methamphetamine, which has led to its classification as a controlled substance in several countries to curb its misuse.
Due to the potential for illicit use in the production of methamphetamine, strict regulations and monitoring are imposed on the production and distribution of 1-phenylpropan-2-one to prevent its diversion to illegal activities.

Upstream product

• 186581-53-3 diazomethane 
• 98-86-2 acetophenone 
• 103-82-2 phenylacetic acid 
• 34713-70-7 2-Phenylpropanal 
• 5413-05-8 ethyl 2-phenylacetoacetate 
• 60212-12-6 1-iodo-2-phenyl-2-methyl-2-ethanol 
• 1855-09-0 1-phenyl-1,2-propandiol 
• 86151-59-9 1-Iodo-3-phenyl-2-propanol 
• 1068-55-9 isopropylmagnesium chloride 
• 114-70-5 sodium phenylacetate 
• 127-08-2 potassium acetate 
• 108-24-7 acetic anhydride 
• 127-09-3 sodium acetate 
• 1555-80-2 phenylacetic anhydride 

Downstream Products

• 56571-97-2 1-(1-methyl-2-phenyl-vinyl)-piperidine 
• 3319-00-4 (+/-)-1-(1-methyl-2-phenylethyl)piperidine 
• 101292-86-8 3-phenyl-5-[4]pyridyl-pentan-2-one 
• 100955-74-6 2-(4-methyl-[2]pyridyl)-1-phenyl-propan-2-ol 
• 55901-59-2 4-[2]furyl-1-phenyl-but-3-en-2-one 
• 100710-55-2 4-(2-methyl-thiazol-4-yl)-3-phenyl-butan-2-one 
• 33244-59-6 2-methyl-3-phenyl-4,5-dihydro-pyrrolo[3,2,1-hi]indole 
• 1030-28-0 isonicotinic acid-(1-methyl-2-phenyl-ethylidenehydrazide) 
• 111066-23-0 2,8-dimethyl-1-phenyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline 
• 41631-40-7 2-methyl-1-phenyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]-quinoline 
• 19279-80-2 8-methoxy-2-methyl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline 
• 108-88-3 toluene 
• 1029-87-4 2,4-Diamino-7-methyl-6-phenyl-pteridin 
• 109696-68-6 1-phenyl-propane-1,2-dione-1-(3-methyl-3H-benzothiazol-2-ylidenehydrazone) 

Relevant academic research and scientific papers

SMALL MOLECULE INHIBITORS OF ACETYL COENZYME A SYNTHETASE SHORT CHAIN 2 (ACSS2)

The present invention relates to compounds of formula (I). The compounds may be used to modulate the acetyl coenzyme A synthetase short chain 2 (ACSS2) protein and may thereby treat, ameliorate or prevent a disease selected from cancer, bacterial infection, viral infection, parasitic infection, fungal infection, neurodegenerative disease, neurological disorder, cerebrovascular disease, cardiovascular disease, non- alcoholic fatty liver disease and obesity. Alternatively, or additionally, the compounds maybe used to promote healthy ageing.

Highly ordered mesoporous hybrid silica functionalized with ionic liquid framework supported copper and its application in the oxidation of alcohols

A highly ordered organic-inorganic hybrid nanomaterial containing copper N-heterocyclic carbene complex (Cu-NHC@Pyrm-OMS) was synthesized and characterized using various techniques including FTIR, MAS NMR, XRD, TGA, SEM, and TEM. Cu-NHC@Pyrm-OMS nanomaterial is highly efficient heterogeneous system towards the selective oxidation of primary and secondary alcohols to corresponding aldehydes and ketones under mild conditions. Moreover, the supported copper nanocatalyst exhibited outstanding stability and could be reused at least ten times, remaining almost unchanged from initial activity. This work has focused on sustainable and green chemistry that use recoverable nanocatalyst, clean oxidant and aqueous media.

An efficient heterogeneous Cu(I) complex for the catalytic oxidation of alcohols and sulfides: synthesis, characterization, and investigation of the catalyst activity

A heterogeneous Cu(I) complex was synthesized by reaction of C5H4NC(O)NHP(O)[NHC(CH3)3]2 (L) with CuCl and used as a catalyst for green oxidation of aromatic alcohols and sulfides. According to the characterization results obtained from 31P NMR, UV-Vis, FT-IR, mass, XRD, elemental analysis, and molar conductivity techniques, the chemical formula of the complex (1) was suggested as [CuClL2]. Parameters on the catalytic activity (reaction temperature, the substrate to oxidant molar ratio, catalyst amount, and solvent type) were optimized, using H2O2 as a green oxidant, and excellent conversion amounts (100%) were achieved under optimal conditions. Moreover, the generality and recyclability of the catalyst were tested and confirmed. A comparison between the oxidation results of the alcohol and sulfide in the presence of 1 with other catalysts indicated that in most cases 1 showed better efficiency, in a more reasonable reaction time and conditions.

Manganese Catalyzed Enantioselective Epoxidation of α,β-Unsaturated Amides with H2O2

Herewith, we report the enantioselective epoxidation of electron-deficient cis- and trans-α,β-unsaturated amides with the environmentally benign oxidant H2O2. The catalysts - manganese complexes with bis-amino-bis-pyridine and structurally related ligands - exhibit reasonably high efficiency (up to 100 TON) and excellent chemo- and enantioselectivity (up to 100% and 99% ee, respectively). Crucially, the cis-enamides epoxidation enantioselectivity and yield are dramatically enhanced by the presence of NH-moiety, which effect can be explained by the hydrogen bonding interaction between the cis-enamide substrate and the manganese based oxygen transferring species. (Figure presented.).

2-Iodosylbenzoic acid activated by trifluoromethanesulfonic anhydride: Efficient oxidant and electrophilic reagent for preparation of iodonium salts

2-Iodosylbenzoic acid in the presence of trifluoromethanesulfonic anhydride is an efficient oxidant and electrophilic reagent useful for preparation of the corresponding alkenyl and aryliodonium salts. Compared to the previously reported methods of electr

Asymmetric Catalytic Epoxidation of Terminal Enones for the Synthesis of Triazole Antifungal Agents

An enantioselective epoxidation of α-substituted vinyl ketones was realized to construct the key epoxide intermediates for the synthesis of various triazole antifungal agents. The reaction proceeded efficiently in high yields with good enantioselectivities by employing a chiral N,N′-dioxide/ScIII complex as the chiral catalyst and 35% aq. H2O2 as the oxidant. It enabled the facile transformation for optically active isavuconazole, efinaconazole, and other potential antifungal agents.

Aerobic epoxidation of styrene over Zr-based metal-organic framework encapsulated transition metal substituted phosphomolybdic acid

Catalytic epoxidation of styrene with molecular oxygen is regarded as an eco-friendly alternative to producing industrially important chemical of styrene oxide (STO). Recent efforts have been focused on developing highly active and stable heterogeneous catalysts with high STO selectivity for the aerobic epoxidation of styrene. Herein, a series of transition metal monosubstituted heteropolyacid compounds (TM-HPAs), such as Fe, Co, Ni or Cu-monosubstituted HPA, were encapsulated in UiO-66 frameworks (denoted as TM-HPA@UiO-66) by direct solvothermal method, and their catalytic properties were investigated for the aerobic epoxidation of styrene with aldehydes as co-reductants. Among them, Co-HPA@UiO-66 showed relatively high catalytic activity, stability and epoxidation selectivity at very mild conditions (313 K, ambient pressure), that can achieve 82 % selectivity to STO under a styrene conversion of 96 % with air as oxidant and pivalaldehyde (PIA) as co-reductant. In addition, the hybrid composite catalyst can also efficiently catalyze the aerobic epoxidation of a variety of styrene derivatives. The monosubstituted Co atoms in Co-HPA@UiO-66 are the main active sites for the aerobic epoxidation of styrene with O2/PIA, which can efficiently converting styrene to the corresponding epoxide through the activation of the in-situ generated acylperoxy radical intermediate.

Markovnikov Wacker-Tsuji Oxidation of Allyl(hetero)arenes and Application in a One-Pot Photo-Metal-Biocatalytic Approach to Enantioenriched Amines and Alcohols

The Wacker-Tsuji aerobic oxidation of various allyl(hetero)arenes under photocatalytic conditions to form the corresponding methyl ketones is presented. By using a palladium complex [PdCl2(MeCN)2] and the photosensitizer [Acr-Mes]ClO4 in aqueous medium and at room temperature, and by simple irradiation with blue led light, the desired carbonyl compounds were synthesized with high conversions (>80%) and excellent selectivities (>90%). The key process was the transient formation of Pd nanoparticles that can activate oxygen, thus recycling the Pd(II) species necessary in the Wacker oxidative reaction. While light irradiation was strictly mandatory, the addition of the photocatalyst improved the reaction selectivity, due to the formation of the starting allyl(hetero)arene from some of the obtained by-products, thus entering back in the Wacker-Tsuji catalytic cycle. Once optimized, the oxidation reaction was combined in a one-pot two-step sequential protocol with an enzymatic transformation. Depending on the biocatalyst employed, i. e. an amine transaminase or an alcohol dehydrogenase, the corresponding (R)- and (S)-1-arylpropan-2-amines or 1-arylpropan-2-ols, respectively, could be synthesized in most cases with high yields (>70%) and in enantiopure form. Finally, an application of this photo-metal-biocatalytic strategy has been demonstrated in order to get access in a straightforward manner to selegiline, an anti-Parkinson drug. (Figure presented.).

Meta Selective C-H Borylation of Sterically Biased and Unbiased Substrates Directed by Electrostatic Interaction

An electrostatically directed meta borylation of sterically biased and unbiased substrates is described. The borylation follows an electrostatic interaction between the partially positive and negative charges between the ligand and substrate. With this strategy, it has been demonstrated that a wide number of challenging substrates, especially 4-substituted substrates, can selectively be borylated at the meta position. Moreover, unsubstituted substrates also displayed excellent meta selectivity. The reaction employs a bench-stable ligand and proceeds at a milder temperature, precluding the need to synthesize a bulky and sophisticated ligand/template.

Gold-Catalyzed [3+2]-Annulations of α-Aryl Diazoketones with the Tetrasubstituted Alkenes of Cyclopentadienes: High Stereoselectivity and Enantioselectivity

This work reports gold-catalyzed [3+2]-annulations of α-diazo ketones with highly substituted cyclopentadienes, affording bicyclic 2,3-dihydrofurans with high regio- and stereoselectivity. The reactions highlights the first success of tetrasubstituted alkenes to undergo [3+2]-annulations with α-diazo carbonyls. The enantioselective annulations are also achieved with high enantioselectivity using chiral forms of gold and phosphoric acid. Our mechanistic analysis supports that cyclopentadienes serve as nucleophiles to attack gold carbenes at the more substituted alkenes, yielding gold enolates that complex with chiral phosphoric acid to enhance the enantioselectivity.