13669-32-4Relevant academic research and scientific papers
Compounds useful as reversible inhibitors of cysteine proteases
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, (2008/06/13)
Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds.
Novel succinate derivative compounds useful as cysteine protease inhibitors
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, (2008/06/13)
Disclosed are novel succinate derivative compounds of the formula (I)/(Ia): wherein R1, R2, R3, R4, R5, R6, R7, X and A are defined herein. The compounds are useful as inhibitors of cysteine proteases. Also disclosed are methods of using and methods of making such compounds.
Succinate derivative compounds useful as cysteine protease inhibitors
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, (2008/06/13)
Disclosed are novel succinate derivative compounds of the formula(I)/(Ia): wherein R1, R2, R3, R4, R5, R6, R7, X and A are defined herein. The compounds are useful as inhibitors of cysteine proteases. Also disclosed are methods of using and methods of making such compounds.
The Role of the Nitrogen Atom in the Hydrogenation of Piperidinones and Methylenepiperidines
Senda, Yasuhisa,Okamura, Kazue,Kuwahara, Mayumi,Ide, Masatoshi,Itoh, Hiroki,Ishiyama, Jun-Ichi
, p. 799 - 803 (2007/10/02)
Dimethylpiperidinones and dimethylmethylenepiperidines have been hydrogenated over several Group 8, 9 and 10 transition metal catalysts and the stereochemistry of the products compared with those of the carbocyclic analogues.The results obtained suggest that intramolecular interactions between the nitrogen lone pair and the unsaturated bond play a major role in determining the stereochemistry of hydrogenation.
