136846-26-9

Upstream product

• 127279-73-6 3β-(4-nitrophenyl)tropane-2β-carboxylic acid methyl ester 
• 50370-54-2 3β-phenyltropane-2β-carboxylic acid methyl ester 
• 50373-10-9 (R)-(-)-anhydroecgonine methyl ester 
• 134052-62-3 3β-(4-aminophenyl)tropane-2β-carboxylic acid methyl ester 
• 50373-10-9 methyl ecgonidine 
• 135416-43-2 (1R,2S,3S,5S)-3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester 
• 50370-54-2 Win 35140 

Relevant academic research and scientific papers

Isomerization study of aryltropane analogs of cocaine

Isomerization of brain imaging agents aryltropane cocaine analogs have been examined by HPLC under chemical conditions similar to those encountered during radiolabeling.

Synthesis, ligand binding, QSAR, and CoMFA study of 3β-(p-substituted phenyl)tropane-2β-carboxylic acid methyl esters

A series of 3β-(p-substituted phenyl)tropane-2β-carboxylic acid methyl esters (2) were synthesized and found to possess high affinity for the cocaine binding site in rat striatum. The p-chloro (2c) and p-iodo (2n) compounds, which were the most potent analogues prepared, were found to be 85 and 78 times more potent than (-)-cocaine. The p-bromo (2m) and p-methyl (2d) were also 56 and 60 times more potent than cocaine. QSAR and CoMFA studies were conducted to correlate binding affinity of the cocaine analogues with their structural features. Whereas the QSAR study gave relatively low correlations, the CoMFA study gave a correlation with high predictive value.