136886-13-0

Basic information

• Product Name: diethyl 1-(4-methylphenyl)-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate
• Synonyms: diethyl 1-(4-methylphenyl)-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate
• CAS NO: 136886-13-0
• Molecular Weight: 391.467
• Mol File: 136886-13-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: diethyl 1-(4-methylphenyl)-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 1-(4-methylphenyl)-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate(136886-13-0)
• EPA Substance Registry System: diethyl 1-(4-methylphenyl)-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate(136886-13-0)

Safety Data

• Hazardous Substances Data: 136886-13-0(Hazardous Substances Data)

Upstream product

• 954374-78-8 ethyl (E)-3-(4-bromo-2-formylphenoxy)acrylate 
• 100-52-7 benzaldehyde 
• 106-49-0 p-toluidine 
• 1613-92-9 (E)-N-benzylidene-4-toluidine 
• 623-47-2 propynoic acid ethyl ester 

Relevant articles and documents

Biological evaluation of 4-aryl-1,4-dihydropyridines as VEGFR-2 kinase inhibitors

Vascular endothelial growth factor-2 receptor (VEGFR-2) kinase is a promising target for the development of novel anticancer drugs. Molecular docking modeling was performed on a series of 4-aryl-1,4-dihydropyridines derivatives to evaluate the structural basis for VEGFR-2 inhibitory activity. Some 4-aryl-1,4-dihydropyridines were synthesized in the reaction of aromatic aldehydes and ethyl propiolate with anilines in acetic acid. The biological activities were evaluated against the cells A549, A431 and Hep-G2. The results indicated that 4-aryl-1,4-dihydropyridines could be the promising potential VEGFR-2 inhibitors.

Catalytic synthesis of 1,4-dihydropyridine derivatives using scandium(III) triflate

Scandium(III) triflate smoothly catalyzed the reaction of imines with ethyl propiolate (2.5 equiv) to produce the corresponding N-substituted 1,4-dihydropyridines in good yields in toluene or BTF under reflux conditions. It also catalyzed the reaction of

SYNTHESIS AND ELECTROCHEMICAL OXIDATION OF 1-ARYL-3,5-DIETHOXYCARBONYL-2,6-UNSUBSTITUTED 1,4-DIHYDROPYRIDINES

The possibility of obtaining 1-aryl-3,5-diethoxycarbonyl-2,6-unsubstituted 1,4-dihydropyridines with electron-acceptor substituents in the N-phenyl radical was demonstrated.The intermediate products of their formation, viz., 2,4-bis(arylaminomethylene)-3-