1369903-46-7

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 1355049-94-3 (3R,4R,5R)-2-(4-aminopyrrole-[2,1-f][1,2,4]-triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-ol 
• 1770840-43-1 7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine 
• 14233-64-8 (3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-dihydro-furan-2-one 
• 937046-98-5 7-bromo-pyrrolo[2,1-f][1,2,4]triazin-4-ylamine 

Downstream Products

• 1911578-75-0 C₂₇H₃₅N₆O₈P 

Relevant academic research and scientific papers

Alpha-configuration nucleoside and application in treating cat coronavirus infection

The present invention provides a method for treating coronavirus infections in cats or other animals by administering a nucleoside represented by a formula (I) and a corresponding prodrug, solvate, orpharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the compound, wherein the nucleoside and the prodrug thereof in the formula (I) are in alpha configuration, and R1, R2, R3 and R4 are all defined in the specification. The formula (I) is defined in the specification.

Development of a Large-Scale Cyanation Process Using Continuous Flow Chemistry en Route to the Synthesis of Remdesivir

The implementation of cyanation chemistry at manufacturing scales using batch equipment can be challenging because of the hazardous nature of the reagents employed and the tight control of reaction parameters, including cryogenic temperatures, that help t

Preparation method of nucleoside analogue

The invention belongs to the technical field of chemical synthesis, and specifically relates to a new preparation method of (2R,3R,4S,5R)-2-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile. The metho

Practical synthesis of 1′-substituted Tubercidin C-nucleoside analogs

Several 1′-substituted analogs of Tubercidin C-nucleosides were prepared using a highly convergent synthesis. Good to high diastereoselectivity was achieved using a variety of nucleophiles targeting the 1′-position. The source for this stereoselectivity i

Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

A series of 1′-substituted analogs of 4-aza-7,9-dideazaadenosine C-nucleoside were prepared and evaluated for the potential as antiviral agents. These compounds showed a broad range of inhibitory activity against various RNA viruses. In particular, the whole cell potency against HCV when R = CN was attributed to inhibition of HCV NS5B polymerase and intracellular concentration of the corresponding nucleoside triphosphate.