1770840-43-1

Basic information

• Product Name: 7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine
• Synonyms: 7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine
• CAS NO: 1770840-43-1
• Molecular Weight: 260.037
• Mol File: 1770840-43-1.mol
• Article Data: 17

Chemical Properties

• Density: 2.43±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine(1770840-43-1)
• EPA Substance Registry System: 7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine(1770840-43-1)

Safety Data

• Hazardous Substances Data: 1770840-43-1(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 1770840-43-1 differently. You can refer to the following data:
1. 4-amino-7-iodopyrrolo[2,1-f][1,2,4]triazine is an amine organic substance and can be used as an intermediate for APIs.
2. 7-Iodopyrrolo[2,1-f][1,2,4]triazin-4-amine is a useful reagent in the synthesis of phosphoramidate GS-5734 prodrug for potential treatment of Ebola virus infections and in the preparation of Remdesivir as COVID-19 antiviral drug candidate.

Upstream product

• 888720-29-4 4-chloropyrrolo[1,2-f][1,2,4]triazine 
• 159326-71-3 pyrrolo<2,1-f><1,2,4>triazin-4(3H)-one 
• 4513-94-4 1H-pyrrole-2-carbonitrile 
• 1003-29-8 2-pyrrole aldehyde 
• 159326-68-8 pyrrolo[2,1-f][1,2,4]triazin-4-amine 

Downstream Products

• 158227-80-6 7-((2S,3S,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-tetrahydrofuran-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine 
• 1911578-75-0 (2S)-2-ethylbutyl 2-(((R)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate 

Relevant articles and documents

Process for synthesizing 7 -iodopyrrolo [2,F] [1,m-triazine -4 - amine

The invention belongs to the technical field of chemical synthesis of medicines, and relates to a synthesis process of 7-iodo pyrrolo [2, 1-F] [1, 2, 4] triazine-4-amine. According to the invention, 2, 5-dimethoxy tetrahydrofuran and acethydrazide are used as initial raw materials, and are subjected to substitution, cyanation, deacetylation, cyclization and iodination reactions to obtain 7-iodopyrrolo [2, 1-F] [1, 2, 4] triazine-4-amine. The preparation method is simple, the initial raw materials are 2, 5-dimethoxytetrahydrofuran and acethydrazide which are cheap and easy to obtain. Meanwhile,the yields of the first four steps all reach 85% or above, the productivity is also greatly improved, the total yield of the product is 50% or above, and the purity can reach 99% or above. And meanwhile, the intermediate product is good in quality, so that the dosage of formamidine acetate is reduced when the intermediate IV is prepared. Through experimental comparison, the route has obvious advantages compared with the traditional process route.

Synthesis method of key intermediate 7-halogenated pyrrolo[1,2-F][1,2,4]triazin-4-amine of remdesivir

The invention discloses a synthesis method of a key intermediate 7-halogenated pyrrolo[1,2-F][1,2,4]triazin-4-amine of remdesivir as shown in a formula (h). Phthalimide is used as a raw material, and the key intermediate 7-halogenated pyrrolo[1,2-F][1,2,4]triazin-4-amine of remdesivir is synthesized through a series of reactions such as substitution, cyclization, bromination, cyano substitution, hydrazinolysis, heterocyclic ring synthesis and iodination . The post-treatment operation is optimized, and the method has the advantages of being short in reaction time, high in yield, suitable for industrial production and the like.

Synthesis process of retegravir intermediate

The invention relates to a synthesis process of a retegravir intermediate 7-iodine-4-amido pyrrolo [2,1-F] [1, 2, 4] triazine. The method comprises the following steps: by using pyrrole as an initialraw material, carrying out aldehyde groupintroduction through phosphorus oxychloride-DMF to obtain 2-aldehyde group pyrrole; preparing a 2-cyano key intermediate through ammonium sulfate, wherein thesteps is the key step of the process; cyclizing the cyano intermediate and formamidine acetate to prepare a 4-amino intermediate; reacting with NIS and adding iodine to prepare the target compound 7-iodine-4-amido pyrrolo [2,1-F] [1, 2, 4] triazine. The whole process has the advantages of simple and easily available raw materials, simple and easy operation, and very high economic value and socialbenefit.