106840-39-5

Upstream product

• 67-56-1 methanol 
• 137-48-4 2-chloro-5-(N-methylsulfamoyl)-nitrobenzene 
• 22117-79-9 4-methoxy-3-nitrobenzene-1-sulfonyl chloride 
• 74-89-5 methylamine 
• 1041598-53-1 4-fluoro-N-methyl-3-nitrobenzenesulfonamide 
• 124-41-4 sodium methylate 
• 1493-27-2 ortho-nitrofluorobenzene 
• 6668-56-0 4-fluoro-3-nitrobenzene-1-sulfonyl chloride 

Downstream Products

• 96-58-2 4-hydroxy-N-methyl-3-nitrobenzenesulfonamide 
• 99969-26-3 3-amino-4-methoxybenzenesulphonic acid methylamide 

Relevant academic research and scientific papers

TRICYCLIC INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION

This invention relates to tricycle I and its therapeutic and prophylactic uses, wherein the variables C1, C2, Z1, Z2, Q, J, R1, and R3 are defined in the specification. Disorders treated and/or prevented include rheumatoid arthritis.

COMPOUNDS AND METHODS

Disclosed are compounds having formula (I), wherein R1, R2, R3, R4, Z1, Z2, Z3 and Z4 are as defined herein, and methods of making and using the same.