137022-91-4

Upstream product

• 220034-64-0 7-(3,5-dibromo-4-hydroxyphenethylamino)-1-tosyl-3,4-dihydropyrrolo[4,3,2-de]quinolin-8(1H)-one 
• 32884-23-4 2-benzyloxy-4-methoxybenzaldehyde 
• 134755-32-1 4-(benzyloxy)-6-methoxy-3-<2-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>ethyl>indole 
• 134755-22-9 ethyl 4-(benzyloxy)-6-methoxyindole-2-carboxylate 
• 143878-19-7 [2-(4-Hydroxy-6-methoxy-1H-indol-3-yl)-ethyl]-carbamic acid 2-trimethylsilanyl-ethyl ester 
• 134755-23-0 <4-(benzyloxy)-6-methoxy-3-indolyl>acetonitrile 
• 138518-15-7 4-(benzyloxy)-6-methoxyindole-2-carboxylic acid 
• 143878-17-5 2-(4-Benzyloxy-6-methoxy-1H-indol-3-yl)-ethylamine 
• 138540-76-8 6-methoxy-4-phenylmethoxy-N,N-dimethyl-3-(1H)-indolemethanamine 
• 138518-16-8 4-benzyloxy-6-methoxy-1H-indole 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 184957-78-6 4-(dimethoxymethyl)-6,7-dimethoxy-5-nitroquinoline 
• 184957-81-1 5-amino-1,2,3,4-tetrahydro-6,7-dimethoxy-4-(dimethoxymethyl)quinoline 
• 175792-34-4 8-chloro-6,7-dimethoxy-4-(dimethoxymethyl)-5-nitroquinoline 

Downstream Products

• 105372-81-4 discorhabdin C 
• 137022-92-5 11,13-dibromo-2,3,5,7,8,9-hexahydro-12-hydroxy-6H-pyrrolo<4',3',2':4,5>quino<8,7-a><3>benzazepin-6-one 

Relevant academic research and scientific papers

Analogs of the marine alkaloid makaluvamines: Synthesis, topoisomerase II inhibition, and anticancer activity

Twelve analogs of makaluvamines have been synthesized. These compounds were evaluated for their ability to inhibit the enzyme topoisomerase II. Five compounds were shown to inhibit topoisomerase catalytic activity comparable to two known topoisomerase II

Synthesis of pyrrolo[4,3,2-de]quinolines from 6,7-dimethoxy-4-methylquinoline. Formal total syntheses of damirones A and B, batzelline C, isobatzelline C, discorhabdin C, and makaluvamines A-D

2-Amino-4-nitrophenol and 2-methoxy-5-nitroaniline were converted into the 5-nitroquinolines 6b and 6d, respectively, and then the latter into nitro-acetal 6f. 6,7-Dimethoxy-4-methylquinoline (6g) was nitrated at C-5 and then the methyl substituent conver

Efficient syntheses of the marine alkaloids makaluvamine D and discorhabdin C: The 4,6,7-trimethoxyindole approach

A new and efficient synthesis of the tricyclic quinonimine 20 as its trifluoroacetate 23 has been developed starting from the commercially available 2,4,5-trimethoxybenzaldehyde and proceeding via the hitherto unknown 4,6,7-trimethoxyindole (7). Quinonimi

Synthetic studies on tetrahydropyrroloquinoline-containing natural products: Syntheses of discorhabdin C, batzelline C and isobatzelline C

Discorhabdin C (1), batzelline C (2) and isobatzelline C (3), metabolites of marine sources sharing a tetrahydropyrroloquinoline core, have been successfully synthesized, and cytotoxicities of several synthetic intermediates were evaluated.

Total synthesis of discorhabdin C: A general aza spiro dienone formation from O-silylated phenol derivatives using a hypervalent iodine reagent

Hypervalent iodine oxidation of O-silylated phenols bearing various types of aminoquinones at the para position in 2,2,2-trifluoroethanol gave azacarbocyclic spiro dienones in good yields. Using this method, the first total synthesis of discorhabdin C, wh

Synthetic studies on novel sulfur-containing alkaloids, prianosins and discorhabdins: Total synthesis of discorhabdin C

The first total synthesis of discorhabdin C, related to the cytotoxic sulfur-containing alkaloids prianosins and discorhabdins is described. The crucial phenolic oxidation of the appropriate phenol carrying no protective group was achieved by electrochemi