1370347-15-1

Basic information

• Product Name: ethyl 2-(4-chloro-3-sulfamoylphenylamino)-2-oxoacetate
• Synonyms: ethyl 2-(4-chloro-3-sulfamoylphenylamino)-2-oxoacetate
• CAS NO: 1370347-15-1
• Molecular Weight: 306.727
• Mol File: 1370347-15-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2-(4-chloro-3-sulfamoylphenylamino)-2-oxoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-chloro-3-sulfamoylphenylamino)-2-oxoacetate(1370347-15-1)
• EPA Substance Registry System: ethyl 2-(4-chloro-3-sulfamoylphenylamino)-2-oxoacetate(1370347-15-1)

Safety Data

• Hazardous Substances Data: 1370347-15-1(Hazardous Substances Data)

Upstream product

• 4533-95-3 5-nitro-2-chlorobenzenesulfonyl chloride 
• 100-00-5 4-chlorobenzonitrile 
• 946-30-5 2-chloro-5-nitrobenzenesulphonic acid sodium salt 
• 96-73-1 2-chloro-5-nitro-benzenesulfonic acid 
• 2015-19-2 5-amino-2-chlorobenzenesulfonamide 
• 4755-77-5 Ethyl oxalyl chloride 

Downstream Products

• 1370347-40-2 ethyl 2-(4-chloro-3-(N-(4-methoxypyrimidin-2-ylcarbamoyl)sulfamoyl)phenylamino)-2-oxoacetate 

Relevant articles and documents

Synthesis and evaluation of novel monosubstituted sulfonylurea derivatives as antituberculosis agents

A series of novel monosubstituted sulfonylurea derivatives 10a-y were synthesized and characterized by 1H NMR, 13C NMR and HRMS. These compounds were evaluated against Mycobacterium tuberculosis H37Rv in vitro. The results showed compounds 10f, 10k and 10s exhibited moderate antituberculosis activities with MIC values in the range of 20-100 mg/L. Compounds 10b and 10o displayed good antituberculosis activities (MIC 10 mg/L), which were comparable with that of the sulfometuron methyl. Both of the two compounds showed little cytotoxicities, with an IC50 against THP-1 cells greater than 100 mg/L.