137092-39-8

Basic information

• Product Name: Propanamide, N-(2-bromophenyl)-N,2,2-trimethyl-
• CAS NO: 137092-39-8
• Molecular Formula: C12H16BrNO
• Molecular Weight: 270.169
• Mol File: 137092-39-8.mol

Chemical Properties

• CAS DataBase Reference: Propanamide, N-(2-bromophenyl)-N,2,2-trimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, N-(2-bromophenyl)-N,2,2-trimethyl-(137092-39-8)
• EPA Substance Registry System: Propanamide, N-(2-bromophenyl)-N,2,2-trimethyl-(137092-39-8)

Safety Data

• Hazardous Substances Data: 137092-39-8(Hazardous Substances Data)

Upstream product

• 3282-30-2 pivaloyl chloride 
• 615-36-1 2-bromoaniline 
• 75-98-9 Trimethylacetic acid 
• 65854-92-4 N-(2-bromophenyl)-2,2-dimethylpropanamide 
• 74-88-4 methyl iodide 
• 6832-87-7 2-bromo-N-methylaniline 

Downstream Products

• 941320-80-5 2,2-dimethyl-1-[2-(methylamino)phenyl]-1-propanone 
• 137092-41-2 N-(2-Bromphenyl)-N-methylpivalinsaeurethioamid 

Relevant articles and documents

Domino Pd0-Catalyzed C(sp3)–H Arylation/Electrocyclic Reactions via Benzazetidine Intermediates

The Pd0-catalyzed C(sp3)-H arylation of 2-bromo-N-methylanilides leads to unstable benzazetidine intermediates that rearrange to benzoxazines through 4π electrocyclic ring-opening and 6π electrocyclization. The introduction of a bulky, non-activatable amide group on the nitrogen atom was key to favor the challenging reductive elimination step and disfavor undesired reaction pathways.

Ruthenium-catalyzed carbon-carbon bond formation via the cleavage of an unreactive aryl carbon-nitrogen bond in aniline derivatives with organoboronates

The RuH2(CO)(PPh3)3-catalyzed reaction of 2-amino-6-methylacetophenone with phenylboronic acid 2,2-dimethyl-1,3-propanediol ester in refluxing toluene gave the corresponding phenylation product in 83% yield via aryl carbon

Electroreduction of Organic Compounds, 19. Formation of Benzoanellated Sulfur Heterocycles by Intramolecular Cathodic Cyclization of Dithiocarboxylic Esters

Cathodic reduction of aryl (3) and benzyl (5) dithiopivaloates and related dithioesters with leaving groups at the benzene ring or a side chain yield the sulfur heterocycles 23, 30 - 32, and 34 depending on the nature of the starting material and the reaction conditions.In the case of the α-oxo-dithioester 22, thioindigo (44) is formed. - The corresponding thioamides 14, 16, and 18 show a strong tendency to reductive dehalogenation but the S,N-heterocycles 38 and 39 are also formed in minor amounts. - The formation of the rearranged products 29 - 32, and 34 isdiscussed in terms of C,S-splitting in the primarily formed radical anion and subsequent C,C-coupling of the fragments and follow-up reactions.Key Words: Dithiopivaloates, S-aryl, S-benzyl / Electroreduction