13711-31-4

Basic information

• Product Name: 4Bromo-25dimethylacetanilide
• Synonyms: 4Bromo-25dimethylacetanilide;N-(4-bromo-2,5-dimethylphenyl)acetamide;4'-BROMO-2',5'-ACETOXYLIDIDE
• CAS NO: 13711-31-4
• Molecular Formula: C₁₀H₁₂BrNO
• Molecular Weight: 242.115
• Product Categories: Anilines, Amides & Amines;Bromine Compounds
• Mol File: 13711-31-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 185 °C
• Boiling Point: 339.8°Cat760mmHg
• Flash Point: 159.3°C
• Appearance: /
• Density: 1.413g/cm³
• Vapor Pressure: 8.94E-05mmHg at 25°C
• Refractive Index: 1.59
• PKA: 14.26±0.70(Predicted)
• CAS DataBase Reference: 4Bromo-25dimethylacetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 4Bromo-25dimethylacetanilide(13711-31-4)
• EPA Substance Registry System: 4Bromo-25dimethylacetanilide(13711-31-4)

Safety Data

• Hazardous Substances Data: 13711-31-4(Hazardous Substances Data)

Usage

General Description

4-Bromo-2,5-dimethylacetanilide is a chemical compound with the molecular formula C10H12BrNO. This synthetic organic compound belongs to the class of chemicals known as acetanilides. It is recognized by its aromatic structure and its bromine substituent. Its primary applications are largely found as a reactant or an intermediate in organic synthesis within chemical research and pharmaceutical industries. However, like most chemicals, improper handling and exposure can pose potential harm to human health, making it necessary for appropriate safety procedures to be followed when working with this compound.

InChI:InChI=1/C10H12BrNO/c1-6-5-10(12-8(3)13)7(2)4-9(6)11/h4-5H,1-3H3,(H,12,13)

Upstream product

• 30273-40-6 4-bromo-2,5-dimethylaniline 
• 15540-81-5 1-bromo-2,5-dimethyl-4-nitrobenzene 
• 95-78-3 2,5-Dimethylaniline 
• 2050-44-4 N-(2,5-dimethylphenyl)acetamide 
• 64-19-7 acetic acid 

Downstream Products

• 30273-40-6 4-bromo-2,5-dimethylaniline 
• 72917-37-4 4-amino-2,5-dimethylbenzonitrile 
• 94881-68-2 4-cyano-2,5-dimethylacetanilide 
• 1202527-97-6 n-propyl-1-methyl-6-phenoxymethyl-1H-indazole-5-carboylate 
• 1202526-93-9 (E)-5-{1-[3-(methanesulfonamide)phenyl]propylidene}-1-methyl-5,11-dihydrobenzo[6,7]oxepino[4,3-f]indazole 
• 1202528-03-7 5-bromo-1-(4-fluorophenyl)-6-methyl-1H-indazole 
• 1202527-98-7 1-methyl-6-phenoxymethyl-1H-indazole-5-carboxylic acid 
• 1202527-96-5 Propyl-6-bromomethyl-1-methyl-1H-indazole-5-carboxylate 
• 1159511-81-5 5-bromo-1,6-dimethylindazole 
• 885223-72-3 5-bromo-6-methyl-1H-indazole 
• 13711-34-7 2-chloro-3,6-dimethyl-aniline 
• 1074-24-4 2,5-dibromo-p-xylene 
• 176385-67-4 3-[N-(2,2-diethoxyethyl)-N-p-tosylaminomethyl]-5,7-dimethoxy-1,4-dimethylcarbazole 
• 177765-97-8 N-(3',5'-dimethoxyphenyl)-4-bromo-2,5-dimethylaniline 

Relevant articles and documents

Synthesis of symmetrical dinitro-and diamino-substituted Troeger's base analogues

This report describes a new synthetic approach to symmetrical diamino-substituted Troeger's base analogues, allowing the synthesis of 1,7-, and 4,10-diamino derivatives with no additional substituents and of 3,9-diamino derivative with methyl groups in the 1-, 4-, 7-and 10-positions. The synthesis uses regioselective nitration of dihalo-substituted-or tetrahalo-substituted Troeger's bases followed either by hydrogenation of the nitro functions accompanied by removal of halogen atoms or alternatively by chemoselective reduction of nitro groups to obtain the dihalo-diamino- substituted Troeger's base analogues. The 2,8-diamino derivatives, not accessible by this approach, can be prepared by Buchwald-Hartwig amination of the 2,8-dibromo-substituted Troeger's bases.

GPR40 RECEPTOR AGONIST, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT

The present invention relates to a novel compound having GPR40 receptor agonist activity that promotes insulin secretion and inhibits blood sugar rise after glucose loading, and is thereby useful for the treatment of diabetes and complications thereof, the preparation method thereof and pharmaceutical composition containing them as an active ingredient.

The oxidative bromination and iodination of dimethylacetanilides

The oxidative bromination and iodination of the six dimethylacetanilides have been examined; whereas bromination of 2,4-dimethyl- and 2,6-dimethylacetanilides using potassium bromide, sodium tungstate and peracetic acid gave predominantly the 6- and 4-bro