13712-74-8Relevant academic research and scientific papers
Cascade Reactions to Substituted 1 H -Pyrrole-3-carbonitriles via Ligand-Free Palladium(II)-Catalyzed C(sp)-C(sp 2) Coupling
Chen, Wenteng,He, Chang,Luo, Haofan,Wang, Zijuan,Yu, Yongping,Zhang, Guolin
, p. 1659 - 1665 (2020)
An efficient and simple synthesis of substituted 1 H -pyrrole-3-carbonitriles was developed. This reaction is a palladium(II)-catalyzed cascade of C(sp)-C(sp 2) coupling followed by intramolecular C-N bond formation. The method can tolerate various substrates with satisfactory yields. Its ligand-free conditions and high efficiency make this method particularly attractive.
New synthesis of unsymmetrically-substituted 2,5-diarylpyrroles from homopropargyl sulfonamides
Van Rossom, Wim,Matsushita, Yoshitaka,Ariga, Katsuhiko,Hill, Jonathan P.
, p. 4897 - 4900 (2014)
Unsymmetrically-substituted 2,5-diarylpyrroles were prepared by 5-endo-dig cyclization with consecutive deprotection of homopropargyl sulfonamides. Stepwise elaboration of an aldehyde allows the introduction of a variety of functional aryl moieties at the
Switchable reactivity between vinyl azides and terminal alkyne by nano copper catalysis
Cen, Jinghe,Wu, Yaodan,Li, Jianxiao,Huang, Liangbin,Wu, Wanqing,Zhu, Zhongzhi,Yang, Shaorong,Jiang, Huanfeng
, p. 2090 - 2094 (2019/03/26)
A novel nano copper-catalyzed substrate-dependent chemodivergent transformation of vinyl azides with a terminal alkyne is disclosed. 2,5-Disubstituted pyrroles were selectively obtained in high yield with aryl alkynes and aliphatic alkynes, whereas 2,3,4-trisubstituted pyrroles were formed with silylated alkynes. This switchable method provides a controllable and facile access to both multisubstituted pyrrole scaffolds with high efficiency, excellent regioselectivity, and good functional group compatibility.
Magnesium nitride as a convenient source of ammonia: Preparation of pyrroles
Veitch, Gemma E.,Bridgwood, Katy L.,Rands-Trevor, Karen,Ley, Steven V.
experimental part, p. 2597 - 2600 (2009/04/08)
The synthesis of a diverse array of pyrroles is reported from the cyclocondensation of 1,4-dicarbonyl compounds with magnesium nitride in methanol.
