137138-52-4

Upstream product

• 74368-00-6 4-allyl-1-ethoxy-2-methoxybenzene 
• 97-54-1 2-methoxy-4-propenylphenol 
• 75-03-6 ethyl iodide 
• 80-40-0 ethyl ester of p-toluenesulfonic acid 
• 102-71-6 triethanolamine 
• 111-90-0 ethoxyethoxyethanol 
• 74-96-4 ethyl bromide 
• 5932-68-3 (E)-2-methoxy-4-(1-propenyl)phenol 
• 93-15-2 1,2-dimethoxy-4-(2-propenyl)benzene 
• 97-53-0 4-allylguaiacol 
• 74-88-4 methyl iodide 

Downstream Products

• 5932-68-3 (E)-2-methoxy-4-(1-propenyl)phenol 
• 63477-41-8 trans-2-ethoxy-5-(1-propenyl)-phenol 
• 3535-30-6 4-ethoxy-3-methoxybenzoic acid 
• 102898-11-3 5-ethoxy-3-(4-ethoxy-3-methoxy-phenyl)-1-ethyl-6-methoxy-2-methyl-indan 
• 195193-01-2 7-Ethoxy-6-methoxy-3-methyl-3,4-dihydro-cyclobuta[a]naphthalene-1,2-dione 
• 120-25-2 4-ethoxy-3-methoxybenzaldehyde 
• 102898-11-3 (+/-)-5-ethoxy-3c-(4-ethoxy-3-methoxy-phenyl)-1r-ethyl-6-methoxy-2t-methyl-indan 

Relevant academic research and scientific papers

Dehydrozingerone, chalcone, and isoeugenol analogues as in vitro anticancer agents

Twenty-eight compounds related to dehydrozingerone (1), isoeugenol (3), and 2-hydroxychalcone (4) were synthesized and evaluated in vitro against human tumor cell replication. Except for isoeugenol analogues 27-35, most compounds exhibited moderate or strong cytotoxic activity against KB, KB-VCR (a multidrug-resistant derivative), and A549 cell lines. In particular, chalcone 15 showed significant cytotoxic activity against the A549 cell line with an IC50 value of 0.6 μg/mL. Furthermore, dehydrozingerone analogue 11 and chalcones 16 and 17 showed significant and similar cytotoxic activity against both KB (IC50 values of 2.0, 1.0, and 2.0 μg/mL, respectively) and KB-VCR (IC50 values of 1.9, 1.0, and 2.0 μ/mL, respectively) cells, suggesting that they are not substrates for the P-glycoprotein drug efflux pump.

Further improvements in isomerization of olefins in solvent-free conditions

Isomerization of safrole and ethyleugenol are performed quasi-quantitatively within 5 minutes at 80°C using KOH or KOtBu and catalytic amount of transfer agent in the absence of solvent. Transfer agent can be avoided in the case of KOtBu with eventually increase in reaction time. Isolated yields of 99% are obtained from 10 g of materials.