137255-86-8

Basic information

• Product Name: (S)-METHYL N-TERT-BUTOXYCARBONYL-3-(4-BIPHENYLYL)-2-AMINOPROPIONATE
• Synonyms: RARECHEM AH CK 0053;(S)-METHYL N-TERT-BUTOXYCARBONYL-3-(4-BIPHENYLYL)-2-AMINOPROPIONATE;METHYL-2-(S)-N-BOC-AMINO-2-BIPHENYL PROPIONATE;(S)-Methyl N-tert-butoxycarbonyl-3-(4-biphenylyl)-2-aminopropionate 98%;(S)-N-TERT-BUTOXYCARBONYL-3-(4-BIPHENYLYL)-2-AMINOPROPANOIC ACID METHYL ESTER;(S)-MethylN-tert-butoxycarbonyl-3-(4-biphenylyl)-2-aminopropionate98%;(S)-Methyl 3-([1,1-biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propanoate
• CAS NO: 137255-86-8
• Molecular Formula: C21H25NO4
• Molecular Weight: 355.43
• Mol File: 137255-86-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 508.6 °C at 760 mmHg
• Flash Point: 261.4 °C
• Appearance: /
• Density: 1.113 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.538
• CAS DataBase Reference: (S)-METHYL N-TERT-BUTOXYCARBONYL-3-(4-BIPHENYLYL)-2-AMINOPROPIONATE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-METHYL N-TERT-BUTOXYCARBONYL-3-(4-BIPHENYLYL)-2-AMINOPROPIONATE(137255-86-8)
• EPA Substance Registry System: (S)-METHYL N-TERT-BUTOXYCARBONYL-3-(4-BIPHENYLYL)-2-AMINOPROPIONATE(137255-86-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 137255-86-8(Hazardous Substances Data)

Usage

General Description

(S)-Methyl N-tert-butoxycarbonyl-3-(4-biphenylyl)-2-aminopropionate is a chemical compound that belongs to the class of amino acid derivatives. It is a derivative of the amino acid phenylalanine and contains a tert-butoxycarbonyl (Boc) protecting group. (S)-METHYL N-TERT-BUTOXYCARBONYL-3-(4-BIPHENYLYL)-2-AMINOPROPIONATE is primarily used in organic synthesis and peptide chemistry as a building block for the synthesis of various peptides and peptidomimetics. It is a white to off-white powder with a molecular weight of 397.482 g/mol. (S)-METHYL N-TERT-BUTOXYCARBONYL-3-(4-BIPHENYLYL)-2-AMINOPROPIONATE is commonly used in the pharmaceutical industry for the development of new drugs and medications.

InChI:InChI=1/C21H25NO4/c1-21(2,3)26-20(24)22-18(19(23)25-4)14-15-10-12-17(13-11-15)16-8-6-5-7-9-16/h5-13,18H,14H2,1-4H3,(H,22,24)/t18-/m0/s1

Upstream product

• 98-80-6 phenylboronic acid 
• 69942-12-7 N-tert-butoxycarbonylserine methyl ester 
• 92-66-0 4-bromo-1,1'-biphenyl 
• 175844-11-8 methyl (2R)-2-[(tert-butoxycarbonyl)amino]-3-bromopropionate 
• 640-60-8 toluene-4-sulfonic acid phenyl ester 
• 112766-18-4 methyl N-(tert-butoxycarbonyl)-O-[(trifluoromethyl)sulfonyl]-L-tyrosinate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 113850-76-3 N-(tert-butoxycarbonyl)-4-iodo-L-phenylalanine methyl ester 
• 591-50-4 iodobenzene 

Downstream Products

• 119273-61-9 N-tert-butoxycarbonyl-p-phenyl-L-phenylalanine 
• 139040-51-0 methyl (S)-2-amino-3-(biphenyl-4-yl)propanoate 
• 149709-63-7 sacubitril 
• 149709-63-7 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid 
• 766480-48-2 (R)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methyl-pentanoic acid ethyl ester 
• 753421-85-1 (R)-4-Amino-5-biphenyl-4-yl-2-methyl-pentanoic acid ethyl ester 
• 63024-30-6 (S)-2-amino-3-(biphenyl-4-yl)-propionic acid methyl ester hydrochloride 

Relevant articles and documents

Synthesis of Enantiopure Unnatural Amino Acids by Metallaphotoredox Catalysis

We describe herein a two-step process for the conversion of serine to a wide array of optically pure unnatural amino acids. This method utilizes a photocatalytic cross-electrophile coupling between a bromoalkyl intermediate and a diverse set of aryl halides to produce artificial analogues of phenylalanine, tryptophan, and histidine. The reaction is tolerant of a broad range of functionalities and can be leveraged toward the scalable synthesis of valuable pharmaceutical scaffolds via flow technology.

SUBSTITUTED HETEROCYCLIC COMPOUNDS

The present invention relates to substituted heterocyclic compounds of Formula I or XI: or pharmaceutically acceptable salts or N-oxides or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are histamine II4 receptor inhibitors useful in the treatment of histamine II4 receptor-associated conditions or diseases or disorders including, for example, inflammatory diseases or disorders, pruritus, and pain.

A new approach for modification of phenylalanine peptides by Suzuki-Miyaura coupling reaction.

For the first time, we have modified phenylalanine peptides by the Suzuki-Miyaura coupling reaction which may be useful in developing combinatorial libraries of peptidomimetics.