1372799-99-9Relevant academic research and scientific papers
Two-directional approach for the rapid synthesis of 2,4-bis-aminoaryl pyridine derivatives
Morgentin, Remy,Barlaam, Bernard,Foote, Kevin,Hassall, Lorraine,Hawkins, Janet,Jones, Clifford D.,Le Griffon, Antoine,Peru, Aurelien,Ple, Patrick
, p. 8 - 24 (2011/10/18)
We have developed two different approaches in parallel to rapidly access 2,4-bis aminoaryl pyridine compounds from a common starting material. The C-4/C-2 approach uses palladium-mediated coupling reactions to sequentially functionalize C-4 and then C-2. An alternative C-2/C-4 route uses a regioselective SNAr reaction to first substitute at C-2 then subsequently at C-4 by a palladium-mediated reaction. Both approaches have been used successfully to provide a range of 2,4-bis-aminoaryl pyridine compounds.
