917343-25-0

Basic information

• Product Name: 2-amino-4-fluoro-N-methylbenzamide
• Synonyms: 2-amino-4-fluoro-N-methylbenzamide
• CAS NO: 917343-25-0
• Molecular Weight: 168.171
• Mol File: 917343-25-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-amino-4-fluoro-N-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-4-fluoro-N-methylbenzamide(917343-25-0)
• EPA Substance Registry System: 2-amino-4-fluoro-N-methylbenzamide(917343-25-0)

Safety Data

• Hazardous Substances Data: 917343-25-0(Hazardous Substances Data)

Upstream product

• 119023-25-5 4-fluoroanthranilamide 
• 446-32-2 4-fluoroanthranilic acid 
• 74-89-5 methylamine 
• 321-50-6 7-fluoro-1H-benzo[d][1,3]oxazine-2,4-dione 
• 96-31-1 N,N'-Dimethylurea 

Downstream Products

• 1372799-99-9 2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-4-fluoro-N-methylbenzamide 
• 1201935-19-4 2-[[2-[(2,5-dimethylpyrazol-3-yl)amino]-5-(trifluoromethyl)-4-pyridyl]amino]-4-fluoro-N-methyl-benzamide 
• 1201934-85-1 2-[[2-[(1,3-dimethylpyrazol-4-yl)amino]-5-(trifluoromethyl)-4-pyridyl]amino]-4-fluoro-N-methyl-benzamide 

Relevant articles and documents

Importance of fluorine in 2,3-dihydroquinazolinone and its interaction study with lysozyme

The main aim of this study is to investigate the interaction of 7-fluoro-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-one with lysozyme through various spectrophotometric studies. The graph such as Stern-Volmer plot, modified Stern Volmer plot, double logarit

Mechanistic insights into a catalyst-free method to construct quinazolinones through multiple oxidative cyclization

A novel one-pot benign oxidative cyclization of alcohols with 2-aminobenzamides was successfully developed without catalyst to afford the quinazolinones under O2. This one-pot protocol involved oxidations and cyclizations to construct the skeleton of quinazolinones through possibly three kinds of distinct reaction mechanisms.

Two-directional approach for the rapid synthesis of 2,4-bis-aminoaryl pyridine derivatives

We have developed two different approaches in parallel to rapidly access 2,4-bis aminoaryl pyridine compounds from a common starting material. The C-4/C-2 approach uses palladium-mediated coupling reactions to sequentially functionalize C-4 and then C-2. An alternative C-2/C-4 route uses a regioselective SNAr reaction to first substitute at C-2 then subsequently at C-4 by a palladium-mediated reaction. Both approaches have been used successfully to provide a range of 2,4-bis-aminoaryl pyridine compounds.