137333-83-6Relevant academic research and scientific papers
Catalysis of Radical Cyclizations from Alkyl Iodides under H2: Evidence for Electron Transfer from [CpV(CO)3H]-
Kuo, Jonathan L.,Lorenc, Chris,Abuyuan, Janine M.,Norton, Jack R.
supporting information, p. 4512 - 4516 (2018/04/10)
Radical cyclizations are most often achieved with Bu3SnH in the presence of a radical initiator, but environmental considerations demand that alternative reagents be developed - ones that can serve as a synthetic equivalent to the hydrogen atom. We have revisited [CpV(CO)3H]-, a known replacement for Bu3SnH, and found that it can be used catalytically under H2 in the presence of a base. We have carried out tin-free catalytic radical cyclizations of alkyl iodide substrates. The reactions are atom-efficient, and the conditions are mild, with broad tolerance for functional groups. We have, for example, achieved the first 5-exo radical cyclization involving attack onto a vinyl chloride. We suggest that the radicals are generated by an initial electron transfer.
Synthesis and some properties of 4′-phenyl-5′-norcarbocyclic adenosine phosphonic acid analogues
Liu, Lian Jin,Kim, Eunae,Hee Hong, Joon
experimental part, p. 1662 - 1668 (2011/12/15)
Steric and electronic parameters of 4′-substituents play significant roles in steering the conformation of nucleoside analogues. In order to investigate the relationship of 4′-substituent with antiviral enhancement, novel 4′-phenyl-5′-norcarbocyclic adeno
Nickel-catalyzed reductive cyclization of organohalides
Kim, Hyejin,Lee, Chulbom
supporting information; experimental part, p. 2050 - 2053 (2011/06/25)
A mild and convenient nickel-catalyzed method for free-radical cyclization of organohalides is described. The use of a NiCl2DME/Pybox complex as the catalyst and zinc powder in methanol efficiently promotes the reductive cyclization of various
THE PALLADIUM-CATALYZED ARYLATION OF 4-H-1,3-DIOXIN
Sakamoto, Takao,Kondo, Yoshinori,Yamanaka, Hiroshi
, p. 6845 - 6848 (2007/10/02)
4H-1,3-Dioxin was firstly arylated by using Heck reaction, and the reaction in the presence of (R)-BINAP gave enantiomerically enriched 4-phenyldioxin which was converted into optically active 1-phenyl-1,3-propanediol.
