137334-84-0

Upstream product

• 19417-59-5 1,4-bis-(3-bromopropyl)-benzene 
• 79-31-2 isobutyric Acid 
• 7549-44-2 dimethyl-1,4-phenylenediacrylate 
• 5312-03-8 dimethyl 3,3'-(1,4-phenylene)dipropanoate 
• 4251-21-2 3,3'-(1,4-phenylene)dipropanoic acid 
• 19417-58-4 [1,4-phenylene]-bis(3-hydroxypropane) 
• 623-27-8 terephthalaldehyde, 
• 35288-49-4 p-phenylenediacrylic diacid dichloride 
• 16323-43-6 1,4-phenylenediacrylic acid 

Downstream Products

• 137334-87-3 1,4-bis<4,4-dimethyl-5-(ethoxycarbonyl)pentyl>benzene 
• 137334-86-2 1,4-bis(6-diazo-4,4-dimethyl-5-oxohexyl)benzene 
• 137334-85-1 1,4-bis<4-(chloroformyl)-4-methylpentyl>benzene 

Relevant academic research and scientific papers

FUNCTIONALIZED LONG-CHAIN HYDROCARBON MONO- AND DI-CARBOXYLIC ACIDS AND THEIR USE FOR THE PREVENTION OR TREATMENT OF DISEASE

This invention provides compounds of Formulae (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (IK), (IL), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof. This invention further provides methods for treating a disease, including but not limited to, liver disease or an abnormal liver condition; cancer (such as hepatocellular carcinoma or cholangiocarcinoma); a malignant or benign tumor of the lung, liver, gall bladder, bile duct or digestive tract; an intra- or extra-hepatic bile duct disease; a disorder of lipoprotein; a lipid-and-metabolic disorder; cirrhosis; fibrosis; a disorder of glucose metabolism; a cardiovascular or related vascular disorder; a disease resulting from steatosis, fibrosis, or cirrhosis; a disease associated with increased inflammation (such as hepatic inflammation or pulmonary inflammation); hepatocyte ballooning; a peroxisome proliferator activated receptor-associated disorder; an ATP citrate lyase disorder; an acetyl-coenzyme A carboxylase disorder; obesity; pancreatitis; or renal disease.

Synthesis and Properties of 4,4,9,9-Tetramethylparacyclophane-5,6,7,8-tetrone

The synthesis of 4,4,9,9-tetramethylparacyclophane-5,6,7,8-tetrone (26) has been achieved in a multistep procedure.Compound 26 is the first cyclic tetraketone whose structure has been studied by X-ray analysis.The key intermediates were 4,4,9,9-tetramethylparacyclophane-6,7-dione (22), 6,7-bis-4,4,9,9-tetramethylparacyclophane-5,7-diene (24), and two epimeric 5,8-dihydroxy-4,4,9,9-tetramethylparacyclophane-6,7-diones 25a and 25b.X-ray analyses have been performed on 24, 25b and 26.That on 24 reveals a dihedral angle of 57 deg between the two silyenol ether groups.The product analyses and the configurations of 25a and 25b together with the isolation of the bis(epoxide) intermediate 28 allow conclusions to be drawn on the oxidation mechanism of 24 with m-CPBA (Rubottom reaction).The stability of 26 is ascribed to steric factors.