1373618-68-8

Basic information

• Product Name: C₁₆H₁₈N₂O₃
• Synonyms: C₁₆H₁₈N₂O₃
• CAS NO: 1373618-68-8
• Molecular Weight: 286.331
• Mol File: 1373618-68-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₈N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₈N₂O₃(1373618-68-8)
• EPA Substance Registry System: C₁₆H₁₈N₂O₃(1373618-68-8)

Safety Data

• Hazardous Substances Data: 1373618-68-8(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 199477-91-3 N-(2-phenylethyl)pyridine-2-carboxamide 
• 1181028-82-9 C₁₅H₁₆N₂O₂ 
• 98-98-6 2-Picolinic acid 
• 2045-79-6 o-methoxy-2-phenylethylamine 
• 64-04-0 phenethylamine 

Relevant articles and documents

Efficient alkyl ether synthesis via palladium-catalyzed, picolinamide-directed alkoxylation of unactivated C(sp3)-H and C(sp2)-H bonds at remote positions

We report the efficient synthesis of alkyl ethers by the functionalization of unactivated sp3- and sp2-hybridized C-H bonds. In the Pd(OAc)2-catalyzed, PhI(OAc)2-mediated reaction system, picolinamide-protected amine substrates undergo facile alkoxylation at the γ or δ positions with a range of alcohols, including t-BuOH, to give alkoxylated products. This method features a relatively broad substrate scope for amines and alcohols, inexpensive reagents, and convenient operating conditions. This method highlights the emerging value of unactivated C-H bonds, particularly the C(sp3)-H bond of methyl groups, as functional groups in organic synthesis.