1374012-92-6Relevant articles and documents
Copper-free route to triazole-modified peptidomimetic by the combination of two multicomponent reactions in one pot
Niu, Teng-Fei,Gu, Lin,Yi, Wen-Bin,Cai, Chun
experimental part, p. 309 - 315 (2012/07/01)
An efficient copper-free protocol for the synthesis of 5-methyl-1H-1,2,3- triazole-modified peptidomimetics through the combination of Ugi four-component reaction with a three-component cycloaddition, has been developed. The copper-free straightforward process is suitable for drug discovery. The chemoselective preparation of 1,4-disubstituted, triazole-modified peptidomimetics by using alkynyl substituted amines may have potential biological and synthetic application. At last, a "Lapinski type" analysis of the physical properties was performed, which is expected to help drug discovery.