1374443-91-0

Basic information

• Product Name: tert-butyl (3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylcarbamate
• Synonyms: tert-butyl (3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylcarbamate
• CAS NO: 1374443-91-0
• Molecular Weight: 544.487
• Mol File: 1374443-91-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl (3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylcarbamate(1374443-91-0)
• EPA Substance Registry System: tert-butyl (3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylcarbamate(1374443-91-0)

Safety Data

• Hazardous Substances Data: 1374443-91-0(Hazardous Substances Data)

Upstream product

• 1374445-12-1 3-bromo-4-oxochroman-7-carbonitrile 
• 1236188-83-2 3-phenyl-4-(trifluoromethyl)isoxazole-5-carbonyl fluoride 
• 1236188-80-9 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylic acid 
• 1236188-79-6 (3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)methanol 
• 214759-65-6 4-oxo-3,4-dihydro-2H-1-benzopyran-7-carbonitrile 
• 932-90-1 syn-benzaldehyde oxime 
• 934-16-7 phenylhydroxamoyl chloride 

Downstream Products

• 1374443-95-4 (3R,4S)-3-amino-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-4-ol trifluoroacetate 
• 1374445-39-2 (4R,5S)-3-((1S,3R)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarbonyl)-4-methyl-5-phenyloxazolidin-2-one 
• 1374445-42-7 (4R,5S)-3-((1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarbonyl)-4-methyl-5-phenyloxazolidin-2-one 
• 1374444-83-3 (1S,3S)-3-((3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylamino)cyclohexanecarboxylic acid trifluoroacetate 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AS S1P1 AGONISTS FOR THE TREATMENT OF AUTOIMMUNE AND VASCULAR DISEASES

Disclosed are compounds of Formula (I) or stereoisomers, salts, or prodrugs thereof, wherein: W is CH2 or O; Q is Formula (II), Formula (III) or Formula (IV); and R1, R2, R3, R4, n, and G are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.