1374451-50-9Relevant academic research and scientific papers
A Strategy for Amide C-N Bond Activation with Ruthenium Catalyst: Selective Aromatic Acylation
Li, Wenkuan,Zhang, Sheng,Feng, Xiujuan,Yu, Xiaoqiang,Yamamoto, Yoshinori,Bao, Ming
supporting information, p. 2521 - 2526 (2021/04/05)
A strategy for amide C-N bond activation with ruthenium catalyst is described for the first time. The in situ formed bis-cycloruthenated complexes were demonstrated to be the key active species with superior oxidative addition ability to an inert amide C-N bond. The direct C-H bond activation of 2-arylpyridines followed by the amide C-N bond activation took place in the presence of a ruthenium precatalyst to produce monoacylation products in moderate to good yields. Synthetically useful functional groups, such as halogen atoms (F and Cl), ester, acetyl, and vinyl, remained intact during tandem C-H/C-N bond activation reactions.
Arylmethyl chlorides: New bifunctional reagents for palladium-catalyzed ortho -chlorination and acylation of 2-arylpyridines
Zhang, Guodong,Sun, Suyan,Yang, Fan,Zhang, Qian,Kang, Jianxun,Wu, Yusheng,Wu, Yangjie
, p. 443 - 450 (2015/02/19)
A chemoselective, palladium-catalyzed, ligand-directed ortho-C-H chlorination and acylation process has been developed, exhibiting high regioselectivity for 2-arylpyridines bearing a meta-substituent. Worthy of note is the fact that arylmethyl chlorides a
Aerobic oxidation of PdII to PdIV by active radical reactants: Direct C-H nitration and acylation of arenes via oxygenation process with molecular oxygen
Liang, Yu-Feng,Li, Xinyao,Wang, Xiaoyang,Yan, Yuepeng,Feng, Peng,Jiao, Ning
, p. 1956 - 1963 (2015/03/14)
A Pd-catalyzed aerobic oxidative C-H nitration and acylation of arenes with simple and readily available tert-butyl nitrite (TBN) and toluene as the radical precursors has been developed. Molecular oxygen is employed as the terminal oxidant and oxygen source to initiate the active radical reactants. Many different directing groups such as pyridine, pyrimidine, pyrazole, pyridol, pyridylketone, oxime, and azo groups can be employed in these novel transformations. The PdII/PdIV catalytic cycle through a radical process is the most likely pathway for these oxidative C-H nitration and acylation reactions.
Direct carbo-acylation reactions of 2-arylpyridines with α-diketones via Pd-catalyzed C-H activation and selective C(sp2)-C(sp2) cleavage
Zhou, Wei,Li, Hongji,Wang, Lei
supporting information, p. 4594 - 4597 (2012/10/29)
An efficient carbo-acylation reaction of 2-arylpyridines with α-diketones via Pd-catalyzed C-H bond activation and C-C bond cleavage in the presence of TBHP was developed that generated aryl ketones in good yields. The highly selective formation of aryl ketones was observed when 2-arylpyridines reacted with aromatic/aliphatic α-diketones.
