1374539-50-0

Upstream product

• 99-90-1 para-bromoacetophenone 
• 10591-75-0 4-bromoacetophenone phenylhydrazone 
• 100-63-0 phenylhydrazine 
• 2234-16-4 1-(2,4-dichlorophenyl)ethan-1-one 
• 36640-41-2 3-(4-bromophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde 

Downstream Products

• 1407096-95-0 3-(4-bromophenyl)-4-(3-(2,4-dichlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1-phenyl-1H-pyrazole 

Relevant academic research and scientific papers

Synthesis of new 3-aryl-4-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)-1-phenyl-1H- pyrazole derivatives as potential antimicrobial agents

New (E)-1-aryl-3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)prop-2-en-1-ones 6 (pyrazolic chalcones) were synthesized from Claisen-Schmidt reaction of 3-aryl-1-phenylpyrazol-4-carboxaldehydes 4 with several acetophenone derivatives 5. Subsequently, the cyclocondensation reaction of chalcones 6 with phenylhydrazine in acetic acid medium afforded the new 3-aryl-4-(3-aryl-4,5- dihydro-1H-pyrazol-5-yl)-1-phenyl-1H-pyrazoles 7. The synthesized compounds were characterized by spectral studies and evaluated for their in vitro antibacterial activity against three pathogenic bacterial strains, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, and in vitro antifungal activity against three pathogenic fungal strains Aspergillus flavus, Chrysosporium keratinophilum, and Candida albicans.