1374586-87-4

Upstream product

• 872689-54-8 (S)-N-butoxycarbonyl-N-methylvaline (1R)-2-methyl-1-[(phenylmethoxy)carbonyl]propyl ester 
• 2441-07-8 benzyl (R)-2-hydroxy-3-methylbutanoate 
• 45170-31-8 Boc-N-Me-Val-OH 
• 100-39-0 benzyl bromide 

Downstream Products

• 1384974-69-9 C₄₅H₇₃N₃O₁₂ 
• 917-13-5 enniatin B 

Relevant academic research and scientific papers

A total synthesis of the ammonium ionophore, (-)-enniatin B

A nine-step (longest linear) batch total synthesis of the cyclic hexadepsipeptide (-)-enniatin B is described. The synthesis minimizes precipitation during reaction conditions for adaptability to flow synthesis. The route was used to prepare >100 mg of th

Rotamers or diastereomers? An overlooked NMR solution

The existence of rotamers in a solution of analyte complicates 1H NMR analysis, especially when the presence of diastereomers is also possible. Organic chemists have often responded to this problem by conducting variable-temperature (VT) NMR experiments, changing NMR solvents, or adding complexing agents. Here, with specific examples, we illustrate the use of simple yet widely overlooked chemical-exchange NMR experiments which allow the nonintrusive rapid distinguishment of rapidly equilibrating small molecules such as rotamers from nonequilibrating diastereomers.