872689-54-8

Upstream product

• 2441-07-8 benzyl (R)-2-hydroxy-3-methylbutanoate 
• 45170-31-8 Boc-N-Me-Val-OH 
• 17407-55-5 (S)-2-Hydroxy-3-methylbutanoic acid 
• 960589-86-0 (S)-2-trimethylsilyloxy-3-methylbutyric acid trimethylsilyl ester 
• 65138-05-8 (S)-2-hydroxy-3-methylbutyric acid benzyl ester 
• 100-39-0 benzyl bromide 

Downstream Products

• 1374586-87-4 C₃₄H₅₄N₂O₉ 

Relevant academic research and scientific papers

Rotamers or diastereomers? An overlooked NMR solution

The existence of rotamers in a solution of analyte complicates 1H NMR analysis, especially when the presence of diastereomers is also possible. Organic chemists have often responded to this problem by conducting variable-temperature (VT) NMR experiments, changing NMR solvents, or adding complexing agents. Here, with specific examples, we illustrate the use of simple yet widely overlooked chemical-exchange NMR experiments which allow the nonintrusive rapid distinguishment of rapidly equilibrating small molecules such as rotamers from nonequilibrating diastereomers.

Synthesis and application of L-N-Boc-N-methyl-β-hydroxyvaline in the preparation of a depsipeptide

Enantiopure (>99% ee) L-N-tert-butyloxycarbonyl-N-methyl-β- hydroxyvaline (2) was synthesized in six steps and 43% overall yield from D-serine methyl ester (5). Methyl (4S)-N-(9-phenylfluoren-9-yl)-oxazolidine-4- carboxylate (7) was prepared in two steps