1375800-67-1

Basic information

• Product Name: (E)-3-(2-fluorophenyl)-2-methyl-N-(2-(1-methylpyrrolidin-2-yl)ethyl)prop-2-en-1-amine
• Synonyms: (E)-3-(2-fluorophenyl)-2-methyl-N-(2-(1-methylpyrrolidin-2-yl)ethyl)prop-2-en-1-amine
• CAS NO: 1375800-67-1
• Molecular Weight: 276.397
• Mol File: 1375800-67-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-3-(2-fluorophenyl)-2-methyl-N-(2-(1-methylpyrrolidin-2-yl)ethyl)prop-2-en-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(2-fluorophenyl)-2-methyl-N-(2-(1-methylpyrrolidin-2-yl)ethyl)prop-2-en-1-amine(1375800-67-1)
• EPA Substance Registry System: (E)-3-(2-fluorophenyl)-2-methyl-N-(2-(1-methylpyrrolidin-2-yl)ethyl)prop-2-en-1-amine(1375800-67-1)

Safety Data

• Hazardous Substances Data: 1375800-67-1(Hazardous Substances Data)

Usage

General Description

The chemical "(E)-3-(2-fluorophenyl)-2-methyl-N-(2-(1-methylpyrrolidin-2-yl)ethyl)prop-2-en-1-amine" is a compound containing a fluorophenyl group and a pyrrolidin-2-yl moiety. It is classified as a prop-2-en-1-amine derivative and is also known as a selective norepinephrine reuptake inhibitor (NRI). This chemical has been studied for its potential therapeutic effects on conditions such as depression and anxiety, as well as its potential use in the development of new pharmaceutical drugs. Its structure and properties make it a subject of interest in medicinal chemistry and pharmaceutical research.

Upstream product

• 51387-90-7 2-(2-AMINOETHYL)-1-METHYLPYRROLIDINE 
• 446-52-6 2-Fluorobenzaldehyde 
• 1375800-37-5 (E)-3-(2-fluorophenyl)-2-methylacrylaldehyde 

Downstream Products

• 1378524-41-4 VUF₁₁₂₀₇ 
• 1378524-61-8 VUF₁₁₄₀₃ 

Relevant articles and documents

Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists

The chemokine receptor CXCR7 is an atypical G protein-coupled receptor as it preferentially signals through the β-arrestin pathway rather than through G proteins. CXCR7 is thought to be of importance in cancer and the development of CXCR7-targeting ligands is of huge importance to further elucidate the pharmacology and the therapeutic potential of CXCR7. In the present study, we synthesized 24 derivatives based on a compound scaffold patented by Chemocentryx and obtained CXCR7 ligands with pKi values ranging from 5.3 to 8.1. SAR studies were supported by computational 3D Fingerprint studies, revealing several important affinity descriptors. Two key compounds (29 and 30, VUF11207 and VUF11403) were found to be high-potency ligands that induce recruitment of β-arrestin2 and subsequent internalization of CXCR7, making them important tool compounds in future CXCR7 research.