137582-40-2

Usage

Uses

Used in Recreational Substances:
Methyl 2-amino-2-benzyl-3-phenylpropanoate is used as a recreational substance for its euphoric effects, providing users with a sense of increased energy, alertness, and euphoria. However, its use is subject to legal restrictions in many countries due to its potential for abuse and addiction.

InChI:InChI=1/C17H19NO2/c1-20-16(19)17(18,12-14-8-4-2-5-9-14)13-15-10-6-3-7-11-15/h2-11H,12-13,18H2,1H3

Upstream product

• 100-39-0 benzyl bromide 
• 100992-42-5 methyl 2-(4-chlorobenzylidene)amino-3-phenylpropionate 
• 131472-74-7 methyl 2-((diphenylmethylene)amino)-3-phenylpropanoate 
• 199184-30-0 N-[1-(methoxycarbonyl)-1-benzyl-2-phenylethyl]benzophenone imine 

Downstream Products

• 1266226-54-3 methyl 3-benzyl-1-oxo-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 

Relevant academic research and scientific papers

Amine-Directed Palladium-Catalyzed C?H Halogenation of Phenylalanine Derivatives

An efficient primary-amine-directed, palladium-catalyzed C?H halogenation (X=I, Br, Cl) of phenylalanine derivatives is reported on a range of quaternary amino acid (AA) derivatives thanks to suitable conditions employing trifluoroacetic acid as additive. The extension of this original native functionality-directed ortho-selective halogenation was even demonstrated with the more challenging native phenylalanine as tertiary AA.

Role of planar chirality of S,N- and P,N-ferrocene ligands in palladium-catalyzed allylic substitutions

Palladium-catalyzed asymmetric allylic substitutions using thioether and phosphino derivatives of ferrocenyloxazoline as ligands have been investigated with a focus on studying the role of planar chirality. In allylic alkylation, up to 98% ee and 95% ee were achieved with S,N- and P,N-ligands, respectively. In allylic amination, 97% ee was realized with P,N-ligands in the presence of TBAF. Several palladium allylic complexes were characterized by X-ray diffraction and/or solution NMR. Thioether derivatives of ferrocenyloxazolines with only planar chirality showed lower enantioselectivity in the allylic alkylation except 5c because of the formation of a new chirality on sulfur atom during the coordination of sulfur with palladium. On the other hand, in the planar chiral P,N-ligands without central chirality, (Sp)-11a-c there was no such disturbance and comparatively higher enantioselectivity in both palladium-catalyzed allylic alkylation and amination was provided.