1376129-52-0

Upstream product

• 58109-40-3 diphenyliodonium hexafluorophosphate 
• 924660-36-6 N-benzyl-2-bromo-4-fluorobenzamide 
• 1006-41-3 2-bromo-4-fluorobenzoic acid 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 95383-36-1 2-bromo-4-fluorobenzoyl chloride 

Downstream Products

• 1376128-30-1 (R)-N-(2-benzyl-2,5-difluoro-2,3-dihydro-1H-inden-1-ylidene)benzamide 

Relevant academic research and scientific papers

Photocatalytic acylarylation of unactivated alkenes with diaryliodonium salts toward indanones and related compounds

A novel photocatalytic acylarylation of unactivated alkenes using diaryliodonium salts as the arylation reagent is described. The reaction produces a variety of 2-benzyl indanones, 3,4-dihydronaphthalen-1(2H)-ones, and 2,3-dihydroquinolin-4(1H)-ones in pr

Ni-Catalyzed Alkene Carboacylation via Amide C-N Bond Activation

We report Ni-catalyzed formal carboacylation of o-allylbenzamides with arylboronic acid pinacol esters. The reaction is triggered by oxidative addition of an activated amide C-N bond to a Ni(0) catalyst and proceeds via alkene insertion into a Ni(II)-acyl bond. The exo-selective carboacylation reaction generates 2-benzyl-2,3-dihydro-1H-inden-1-ones in moderate to high yields (46-99%) from a variety of arylboronic acid pinacol esters and substituted o-allylbenzamides. These results show that amides are practical substrates for alkene carboacylation via amide C-N bond activation, and this approach bypasses challenges associated with alkene carboacylation triggered by C-C bond activation.