1376293-70-7

Upstream product

• 59259-01-7 2-<2-(1,3-dioxolanyl)>benzaldehyde 
• 1439-43-6 1-(4-nitro-phenyl)-2-(triphenyl-λ⁵-phosphanylidene)-ethanone 
• 34824-58-3 2-(2-bromophenyl)-1,3-dioxolan 
• 6630-33-7 ortho-bromobenzaldehyde 
• 99-81-0 4-Nitrophenacyl bromide 

Downstream Products

• 1376293-47-8 1-[2-(4-nitrophenyl)-2-oxoethyl]-3-phenyl-3,4-dihydro-1H-2,3-benzoxazin-4-one 

Relevant academic research and scientific papers

Nonenzymatic Dynamic Kinetic Resolution of in situ Generated Hemithioacetals: Access to 1,3-Disubstituted Phthalans

The first nonenzymatic DKR reaction of hemithioacetals is developed. Hemithioacetals were formed in situ via thiol addition and subsequently underwent an intramolecular oxa-Michael reaction. The scope of the reaction was quite broad ranging from aliphatic to aromatic substituents and 1,3-disubstituted-1,3-dihyroisobenzofuran products were obtained in good yields with moderate diastereoselectivities and high enantioselectivities. (Figure presented.).