137644-93-0

Upstream product

• 89244-39-3 (2-methoxy-6-methylphenyl)methanol 
• 79383-44-1 methyl 2-methyl-6-methoxybenzoate 
• 6161-65-5 2-methoxy-6-methyl-benzoic acid 
• 2944-49-2 2,3-dimethylanisole 
• 4885-02-3 Dichloromethyl methyl ether 
• 27060-75-9 4-bromo-3-methylanisole 
• 54884-55-8 2-methoxy-6-methyl-benzaldehyde 

Downstream Products

• 1192172-68-1 ethyl 5-bromo-4-methylbenzofuran-2-carboxylate 

Relevant academic research and scientific papers

FXR receptor agonist

The present invention discloses an FXR receptor agonist, belongs to the technical field of medicine, and particularly relates to a compound represented by a formula (I), a pharmaceutically acceptablesalt, an ester or a stereoisomer thereof, wherein R, R, R, M, L, L1, W, A , B, Q, m and n are defined in the specification. The present invention further relates to a preparation method of the compound, a pharmaceutical preparation, and applications in preparation of drugs for treatment and/or prevention of nonalcoholic fatty liver disease, primary biliary cirrhosis, lipid metabolism disorder, diabetic complication, malignant tumors and other related diseases mediated by FXR receptors. The formula I is defined in the specification.

Synthesis of (+)-varitriol analogues via novel and versatile building blocks based on julia olefination

The synthesis of (+)-varitriol (1) analogues was achieved through, the use of Julia olefination. The potential anticancer properties of 1 coupled with, our interest in developing building blocks that enable olefin formation under the Julia protocol constitute the basis of our research project. Efforts are aimed at the synthesis of building blocks 2 and 3 and to explore their use towards the synthesis of (+)-varit:riol analogues. Herein, we would, like to present the synthesis of building block 3 and its ability to react with variety of substituted aromatic-, heterocyclic- and carbohydrate-derived aldehydes to yield alkene 6 in moderate to good yields with E as the major isomer. The successful, coupling of 2 with (furanoside moieties) aldehydes 5k, 5m and 5n in particular and the obtainment of compound 23 reflect the promise associated with the new strategy.

Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators

The present invention relates to compounds of formula (I) wherein the substituents are as defined in the claims, including pharmaceutical compositions thereof and for their use in the treatment and/or prevention and/or amelioration of one or more symptoms

PIPERIDINE DERIVATIVE AS TACHYKININ RECEPTOR ANTAGONIST

The present invention relates to a compounds represented by the formula. The compounds of the present invention have a superior tachykinin receptor antagonistic action, particularly a substance P receptor antagonistic action, and is useful as pharmaceutical agents, for example, tachykinin receptor antagonists, agents for the prophylaxis or treatment of lower urinary tract symptoms, gastrointestinal diseases or central nerve diseases.

Pseudoguaianolides from Intramolecular Cycloadditions of Aryl Diazoketones: Synthesis of (+/-)-Confertin and an Approach to the Synthesis of (+/-)-Damsin

Rhodium(II) mandelate-catalysed cyclisation of α-diazoketones derived from 3-arylpropionic acids produces bicyclodecatrienones, one of which has been used to synthesise an advanced (+/-)-confertin intermediate in six stages and 20percent overall yield.The possibility of constructing intermediates for the synthesis of damsin-like pseudoguaianolides via catalysed diazoketone cyclisation is also examined and methods for the construction of polyfunctional 3-arylpropionic acids suitable for use as damsin precursors are presented.