136740-98-2

Upstream product

• 63700-05-0 1,2;5,6-dianhydro-3,4-O-isopropylidene-D-mannitol 
• 3969-84-4 3,4-di-O-isopropylidene-D-mannitol 
• 136740-96-0 (2R,3R,4R,5R)-3,4-O-isopropylidene-1,6-diphenyl-2,3,4,5-hexanetetraol 
• 69-65-8 mannitol 

Downstream Products

• 129491-63-0 (2S,3R,4R,5S)-2,5-bis[(1,1-dimethylethoxy)carbonyl]amino-1,6-diphenyl-3,4-dihydroxyhexane 
• 137649-75-3 (4S,5R,4'S,5'R)-5,5'-bis(4-benzyloxazolidin-2-one) 
• 134805-49-5 (2S,3R,4R,5S)-2,5-diamino-3,4-dihydroxy-1,6-diphenylhexane 
• 129467-48-7 A-75925 
• 138328-92-4 (2S,3R,4R,5S)-2,5-Diazido-1,6-diphenyl-hexane-3,4-diol 

Relevant academic research and scientific papers

Inhibitors of retroviral proteases

The present invention relates to compounds of the formula I STR1 wherein A, Y, R2, R3, R4, R5, R6, l, m and the corresponding radicals labeled with * are defined as stated in the description, a process for their preparation and their use for the inhibition of retroviral proteases.

Stereocontrolled synthesis of HIV-1 protease inhibitors with C2-axis of symmetry

An efficient and stereocontrolled synthesis of various C2-symmetric HIV-1 protease inhibitors is described, starting from commercially available and inexpensive D-mannitol.