137684-79-8

Usage

Imidazole derivative

Yes

Contains ethoxy and phenyl groups

Yes

Presence of sulfur

Yes, suggests thiol-like properties

Potential biological activities

Antifungal, antibacterial, and anti-inflammatory properties

Potential pharmacological and medicinal applications

Possible, but requires further research to understand its properties and potential uses.

Upstream product

• 100-52-7 benzaldehyde 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 2349-58-8 4,5-Diphenylimidazole-2-thione 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 

Relevant academic research and scientific papers

Acyl-CoA::cholesterol O-Acyl Transferase (ACAT) Inhibitors. 1. 2-(Alkylthio)-4,5-diphenyl-1H-imidazoles as Potent Inhibitors of ACAT

A potent, bioavailable ACAT inhibitor may have beneficial effects in the treatment of atherosclerosis by (i) reducing the absorption of dietary cholesterol, (ii) reducing the secretion of very low density lipoproteins into plasma from the liver, and (iii) preventing the transformation of arterial macrophages into foam cells.We have found that a mevalonate derivative 2, which contains a 4,5-diphenyl-1H-imidazol-2-yl moiety, inhibits rat hepatic microsomal ACAT in vitro and produces a significant hypocholesterolemic effect in the cholesterol-fed rat.Structure-activity relationships for analogues of 2 demonstrate that the 4,5-diphenyl-1H-imidazole moiety is a pharmacophore for inhibition of rat microsomal ACAT.