13771-67-0Relevant academic research and scientific papers
MODULATORS FOR NICOTINIC ACETYLCHOLINE RECEPTOR α2 AND α4 SUBUNITS
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Page/Page column 37; 41; 42, (2016/12/22)
Positive allosteric modulators (PAMs) of nicotinic acetylcholine receptors (nAChR) are important therapeutic candidates as well as valuable research tools. We identified a novel type II PAM, (R)-7-bromo-N-(piperidin-3-yl)benzo[b]thiophene-2-carboxamide (B
Palladium(II)/polyoxometalate-catalyzed direct alkenylation of benzofurans under atmospheric dioxygen
Huang, Qiufeng,Ke, Shaojia,Qiu, Lin,Zhang, Xiaofeng,Lin, Shen
, p. 1531 - 1534 (2014/06/24)
An efficient and selective C2 alkenylation of benzofurans was performed by using Pd(OAc)2 combined with a catalytic amount of 11-molybdovanadophosphoric acid (H4PMo11VO40) under an atmosphere of dioxygen. N-Acetylglycine (Ac-Gly-OH) was observed to be an effective additive for the olefination reaction. A tolerant POM: The efficient and selective direct alkenylation of benzofurans is achieved by using palladium acetate combined with 11-molybdovanadophosphoric acid. The transformation is performed under an atmosphere of dioxygen. Functional groups such as ethoxy, cyano, chloro, bromo, and ester are tolerated under the reaction conditions, and N-acetylglycine (Ac-Gly-OH) appears to be an effective additive for this reaction. 1 atm=101.3 kPa.
Reaction Pathways for the Cyclization of ortho-Thioalkyl and ortho-Thioaryl Substituted Phenyl Radicals with Alkynes. Reaction of o-Methylthioarenediazonium Tetrafluoroborates with Alkynes to give 2-Substituted Benzothiophenes
Leardini, Rino,Pedulli, Gian Franco,Tundo, Antonio,Zanardi, Giuseppe
, p. 1390 - 1391 (2007/10/02)
An easily effected aromatic annelation is described involving reaction of o-thioalkyl and o-thioaryl substituted phenyl radicals with alkynes to give 2-substituted benzothiophenes; the mechanism is discussed.
