1378110-08-7

Basic information

• Product Name: N-(2-(piperidin-4-yloxy)phenyl)pyridine-2-sulfonamide trifluoroacetate
• Synonyms: N-(2-(piperidin-4-yloxy)phenyl)pyridine-2-sulfonamide trifluoroacetate
• CAS NO: 1378110-08-7
• Molecular Weight: 447.435
• Mol File: 1378110-08-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2-(piperidin-4-yloxy)phenyl)pyridine-2-sulfonamide trifluoroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-(piperidin-4-yloxy)phenyl)pyridine-2-sulfonamide trifluoroacetate(1378110-08-7)
• EPA Substance Registry System: N-(2-(piperidin-4-yloxy)phenyl)pyridine-2-sulfonamide trifluoroacetate(1378110-08-7)

Safety Data

• Hazardous Substances Data: 1378110-08-7(Hazardous Substances Data)

Upstream product

• 690632-14-5 C₁₆H₂₄N₂O₃ 
• 690632-03-2 4-(2-nitrophenoxy)-piperidine-1-carboxylic acid tert-butyl ester 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 88-75-5 2-hydroxynitrobenzene 
• 1378110-13-4 N-(2-(piperidin-4-yloxy)phenyl)pyridine-2-sulfonamide trifluoroacetate 
• 76-05-1 trifluoroacetic acid 

Relevant articles and documents

DERIVATIVES OF HETEROARYLSULFONAMIDES, THEIR PREPARATION AND THEIR APPLICATION IN HUMAN THERAPY

The present invention concerns derivatives of heteroarylsulfonamides, notably as blockers of Kv potassium channels, and more particularly of channels Kv1.5, Kv4.3 or Kv11.1, their application in clinical therapy and their preparation methods. These compounds correspond to the following general formula (I): where R1 represents one or more substituents of the phenyl core X such as: hydrogen, halogen, trifluoromethyl, trifluoromethoxy, linear or branched C1-C4 alkyl, or linear or branched C1-C4 alkoxy, A represents oxygen or sulphur, B represents nitrogen when n=1 or 2 and D represents ?C(=O)-, or B represents CH when n=0 and D represents ?CH2O? or when n=1 and D represents ?O?, R2 represents a hydrogen, a methyl, a fluorine or chlorine atom or a methoxy, HetAr represents a pyridyl or quinolyl group, possibly substituted by a group such as a linear or branched C1-C4 alkyl, a linear or branched C1-C4 alkoxy, a halogen, or a trifluoromethyl, and to their pharmaceutically acceptable salts.