1378860-76-4

Basic information

• Product Name: 7-broMo-5-Methoxyquinoline
• Synonyms: 7-broMo-5-Methoxyquinoline
• CAS NO: 1378860-76-4
• Molecular Formula: C₁₀H₈BrNO
• Molecular Weight: 238.08062
• Mol File: 1378860-76-4.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 7-broMo-5-Methoxyquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 7-broMo-5-Methoxyquinoline(1378860-76-4)
• EPA Substance Registry System: 7-broMo-5-Methoxyquinoline(1378860-76-4)

Safety Data

• Hazardous Substances Data: 1378860-76-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Medicinal Chemistry:
7-Bromo-5-methoxyquinoline is used as a pharmaceutical compound for its diverse biological activities, including antimalarial, antifungal, and antibacterial properties. Its unique structure and potential therapeutic effects make it a promising candidate for the development of new drugs and treatments.
Used in Organic Synthesis:
7-Bromo-5-methoxyquinoline is used as a building block in the synthesis of other organic compounds and materials. Its specific properties and reactivity contribute to the creation of new chemical entities with potential applications in various industries, such as pharmaceuticals, agrochemicals, and materials science.
Used in Research and Development:
7-Bromo-5-methoxyquinoline is used as a valuable chemical for research and development in the field of chemistry. Its unique structure and potential applications make it an interesting subject for further exploration, leading to the discovery of new compounds, reactions, and applications.

Upstream product

• 34522-69-5 5,7-dibromoquinoline 
• 124-41-4 sodium methylate 
• 16618-68-1 3-bromo-5-methoxyaminobenzene 
• 56-81-5 glycerol 

Downstream Products

• 1421339-93-6 2-((7-(4-(methylsulfonyl)phenyl)quinolin-5-yloxy)methyl)nicotinamide 
• 1261677-80-8 7-bromo-5-hydroxy-quinoline 

Relevant articles and documents

Synthesis method of 7-bromo-5-methoxyquinoline

The invention discloses a synthesis method of 7-bromo-5-methoxyquinoline, which comprises the following steps: carrying out Skraup condensation reaction on 3, 5-dibromoaniline serving as a raw material and glycerol to obtain 5, 7-dibromoquinoline, reacting with sodium methoxide to obtain 5-bromo-7-methoxyquinoline and 7-bromo-5-methoxyquinoline, and finally carrying out column chromatography purification and separation to obtain the 7-bromo-5-methoxyquinoline. The method overcomes the defects of low yield, microwave condition requirement, difficulty in post-treatment, difficulty in amplification and the like in the existing synthesis process. According to the synthetic method, the 3, 5-dibromoaniline is used as a raw material, the process selection is reasonable, the raw material cost is low, the raw materials are simple and easy to obtain, the operation and post-treatment are convenient, the total yield is high, a highly toxic reagent is not used, amplification is easy, and large-scale production can be carried out.

SUBSTITUTED QUINOLINES AND THEIR USE AS MEDICAMENTS

The invention relates to new substituted quinolines of formula (1) wherein R1 is a linear or branched C1-6-alkyl, wherein R1 may optionally be substituted by R3 which is selected from the group consisting of a three-, four-, five-, six- or seven-membered cycloalkl; a five-, six- or seven-membered, saturated heterocycle comprising one, two or three heteroatoms each independently selected from the group consisting of N, S and O; and a five- or six-membered heteroaryl comprising one, two or three heteroatoms each independently selected from the group consisting of N, S and O; wherein R3 may optionally be substituted further substituted as defined in claim 1 and wherein R2 is selected from the group consisting of halogen, phenyl, a five- or six-membered monocyclic heteroaryl comprising one, two or three heteroatoms each independently selected from the group consisting of N, S and O; a bicyclic, nine-, ten- or eleven-membered, either aromatic or non-aromatic, but not fully saturated heterocycle comprising one, two, three or four heteroatoms each independently selected from the group consisting of N, S and O; wherein R2 may optionally be further substituted as defined in claim 1, and their use in the preparation of medicaments for the treatment of disease such as asthma, COPD, allergic rhinitis, allergic dermatitis and rheumatoid arthritis.

Substituted Quinolines and Their Use As Medicaments

Disclosed are substituted quinolines of formula 1 wherein R1 and R2 are defined herein, the processing of making and using the same.