1378860-76-4

Basic information

• Product Name: 7-broMo-5-Methoxyquinoline
• Synonyms: 7-broMo-5-Methoxyquinoline
• CAS NO: 1378860-76-4
• Molecular Formula: C₁₀H₈BrNO
• Molecular Weight: 238.08062
• Mol File: 1378860-76-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 7-broMo-5-Methoxyquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 7-broMo-5-Methoxyquinoline(1378860-76-4)
• EPA Substance Registry System: 7-broMo-5-Methoxyquinoline(1378860-76-4)

Safety Data

• Hazardous Substances Data: 1378860-76-4(Hazardous Substances Data)

Usage

General Description

7-Bromo-5-methoxyquinoline is a chemical compound that belongs to the quinoline family. It is characterized by the presence of a bromine atom and a methoxy group on the quinoline ring. This chemical compound has potential applications in pharmaceutical and medicinal chemistry, as quinoline derivatives are known for their diverse biological activities, including antimalarial, antifungal, and antibacterial properties. 7-Bromo-5-methoxyquinoline may also be used as a building block in the synthesis of other organic compounds and materials. Its specific properties and potential uses make it an interesting and valuable chemical for further research and development.

Upstream product

• 34522-69-5 5,7-dibromoquinoline 
• 124-41-4 sodium methylate 
• 16618-68-1 3-bromo-5-methoxyaminobenzene 
• 56-81-5 glycerol 

Downstream Products

• 1261677-80-8 7-bromo-5-hydroxy-quinoline 
• 1421339-93-6 2-((7-(4-(methylsulfonyl)phenyl)quinolin-5-yloxy)methyl)nicotinamide 

Relevant articles and documents

Synthesis method of 7-bromo-5-methoxyquinoline

The invention discloses a synthesis method of 7-bromo-5-methoxyquinoline, which comprises the following steps: carrying out Skraup condensation reaction on 3, 5-dibromoaniline serving as a raw material and glycerol to obtain 5, 7-dibromoquinoline, reacting with sodium methoxide to obtain 5-bromo-7-methoxyquinoline and 7-bromo-5-methoxyquinoline, and finally carrying out column chromatography purification and separation to obtain the 7-bromo-5-methoxyquinoline. The method overcomes the defects of low yield, microwave condition requirement, difficulty in post-treatment, difficulty in amplification and the like in the existing synthesis process. According to the synthetic method, the 3, 5-dibromoaniline is used as a raw material, the process selection is reasonable, the raw material cost is low, the raw materials are simple and easy to obtain, the operation and post-treatment are convenient, the total yield is high, a highly toxic reagent is not used, amplification is easy, and large-scale production can be carried out.

Substituted Quinolines and Their Use As Medicaments

Disclosed are substituted quinolines of formula 1 wherein R1 and R2 are defined herein, the processing of making and using the same.