7-Bromo-5-methoxyquinoline

Base Information

• Chemical Name: 7-Bromo-5-methoxyquinoline
• CAS No.: 1378860-76-4
• Molecular Formula: C10H8BrNO
• Molecular Weight: 238.084
• Hs Code.: 2933499090
• Mol file: 1378860-76-4.mol

Synonyms:QC-5173;7-bromo-5-methoxy-quinoline;

Chemical Property of 7-Bromo-5-methoxyquinoline

Chemical Property:

• PSA: 22.12000
• LogP: 3.00590
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

NLT 98% ^*data from raw suppliers

7-bromo-5-methoxyquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Bromo-5-methoxyquinoline

There total 2 articles about 7-Bromo-5-methoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

3-bromo-5-methoxyaminobenzene (16618-68-1) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 7-bromo-5-methoxy-quinoline (1378860-76-4) + 5-bromo-7-methoxy-quinoline (1126824-44-9)

Guidance literature:

3-bromo-5-methoxyaminobenzene; glycerol; With sulfuric acid; In nitrobenzene; at 150 ℃; for 3h; Darkness;

With sodium hydroxide; In water; ethyl acetate; nitrobenzene; Overall yield = 74 %; Overall yield = 3.5 g; Cooling with ice;

Reference yield:

5,7-dibromoquinoline (34522-69-5) + sodium methylate (124-41-4) → 7-bromo-5-methoxy-quinoline (1378860-76-4) + 5-bromo-7-methoxy-quinoline (1126824-44-9)

Guidance literature:

In methanol; N,N-dimethyl-formamide; at 60 ℃; for 2h; Overall yield = 75 percent;

Reference yield: 47.8%

7-bromo-5-methoxy-quinoline (1378860-76-4) → 7-bromo-5-hydroxy-quinoline (1261677-80-8)

Guidance literature:

With hydrogen bromide; at 120 ℃; for 12h;

upstream raw materials:

3-bromo-5-methoxyaminobenzene

glycerol

5,7-dibromoquinoline

sodium methylate

Downstream raw materials:

7-bromo-5-hydroxy-quinoline

2-((7-(4-(methylsulfonyl)phenyl)quinolin-5-yloxy)methyl)nicotinamide

Refernces

• 1、 -. "SUBSTITUTED QUINOLINES AND THEIR USE AS MEDICAMENTS". Page/Page column 49. . Retrieved 2013/03/26.