1378949-53-1Relevant articles and documents
Double-sided α-helix mimetics
Thompson, Sam,Vallinayagam, Ramakrishnan,Adler, Marc J.,Scott, Richard T.W.,Hamilton, Andrew D.
, p. 4501 - 4505 (2012/07/17)
The design and synthesis of substituted bis- and tris-benzamides is reported in which the projection of side-chain residues on both sides of an α-helix is reproduced. The scaffold is conformationally constrained by a series of intramolecular hydrogen bonds, allowing for spatial and angular mimicry of the i, i+2, i+4 and i+6 side-chains in the case of the bis-benzamide, and may be extended to higher-order oligomers.