137946-40-8Relevant academic research and scientific papers
3H-THIENO[3,4]PYRIMIDIN-4-ONEAND PYRROLOPYRIMID-4-ONE AS GRAM-POSITIVE ANTIBACTERIAL AGENTS
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Page/Page column 41; 98, (2015/09/28)
The invention relates to novel heteroaromatic derivatives of formula (I) and their addition salts thereof with acids and bases; their preparation, their use as drugs and pharmaceutical compositions and associations containing them. wherein A, B, T, V, X and Y represent organic substituents as defined herein, The compounds of formula (I) are able to inhibit the activity of the Gram-positive bacterial DltA enzyme and they are used to prevent and/or treat Gram-positive bacterial infections in humans or animals, alone or in association with antibacterials, antivirulence agents or drugs reinforcing the host innate immunity,
Regiochemical Control of the Ring-Opening of 1,2-Epoxides by Means of Chelating Processes. 2. Synthesis and Reactions of the cis- and trans-Oxides of 4-cyclohexene, 3-Cyclohexenemethanol, and Methyl 3-Cyclohexenecarboxylate
Chini, Marco,Crotti, Paolo,Flippin, Lee A.,Macchia, Franco,Pineschi, Mauro
, p. 1405 - 1412 (2007/10/02)
The synthesis of the diastereoisomeric epoxides cis-1b-d and trans-2b-d and the products of their ring-opening by various nucleophiles are described.The results of the ring-openings of the trans-epoxides 2b-d can be rationalized by combining stereoelectro
