1379587-55-9Relevant academic research and scientific papers
Regio- and Chemoselective Formation of Spiroindolinone-Isoindolinone by a Palladium-Catalyzed Buchwald-Hartwig Addition-Elimination Sequence
Butani, Himanshu H.,Vachhani, Dipak D.,Bhoya, Umed C.,Shah, Anamik K.,Van Der Eycken, Erik V.
, p. 6634 - 6638 (2014)
The usual way to synthesize spiroindolinones is the application of isatin derivatives. Here, we report the first Pd-catalyzed Buchwald-Hartwig addition-elimination strategy for the formation of the spiroindolinone-isoindolinone architecture. The applicati
Facile access to functionalized spiro[indoline-3,2′-pyrrole]-2, 5′-diones via post-Ugi domino Buchwald-Hartwig/Michael reaction
Sharma, Nandini,Li, Zhenghua,Sharma, Upendra K.,Van Der Eycken, Erik V.
supporting information, p. 3884 - 3887 (2014/08/18)
A novel access to spiro[indoline-3,2′-pyrrole]-2,5′-diones is presented via a palladium-catalyzed post-Ugi cascade cyclization approach involving a Buchwald-Hartwig/Michael reaction sequence. The method allows the easy construction of a library of spirooxindoles in moderate to good yields starting from readily available precursors. In addition, alkynoic acids are replaced with α,β-unsaturated acids leading to variably substituted spirooxindoles.
A ligand-free Pd-catalyzed cascade reaction: An access to the highly diverse isoquinolin-1(2 H)-one derivatives via isocyanide and Ugi-MCR synthesized amide precursors
Tyagi, Vikas,Khan, Shahnawaz,Giri, Archana,Gauniyal, Harsh M.,Sridhar,Chauhan, Prem M. S.
supporting information; experimental part, p. 3126 - 3129 (2012/07/17)
A novel ligand-free palladium-catalyzed cascade reaction for the synthesis of highly diverse isoquinolin-1(2H)-one derivatives from isocyanide and amide precursors synthesized by Ugi-MCR has been developed. A broad variety of acids, amines, and isocyanide
