1379771-63-7

Upstream product

• 2280-44-6 D-Glucose 
• 2847-00-9 1,2:5,6-di-O-isopropylidene-α-D-hexofuran-3-ulose 
• 100-39-0 benzyl bromide 
• 26275-20-7 1,2-O-isopropylidene-6-O-p-toluenesulfonyl-α-D-allofuranose 
• 2595-05-3 Diacetone D-glucose 
• 582-52-5 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 

Relevant academic research and scientific papers

Sugar-amino acid cyclic conjugates as novel conformationally constrained hydroxyethylamine transition-state isosteres

Hydroxyethylamine (HEA) isosteres have previously been shown to display a multitude of biomedical applications. In fact, the first protease inhibitor, saquinavir is an HEA based peptidomimetic. Herein we describe an easy-to-operate synthetic route to a series of carbohydrate-based conformationally constrained hydroxyethylamine (HEA) isosteres featuring amino acid side chains, starting from d-glucose. This class of novel sugar-amino acid-tethered conformationally restricted HEA systems may have bearing in practical application, particularly in the development of conformationally restricted protease inhibitors.