138037-04-4

Basic information

• Product Name: Benzamide, N-[phenyl(trimethylsilyl)methyl]-
• CAS NO: 138037-04-4
• Molecular Formula: C17H21NOSi
• Molecular Weight: 283.445
• Mol File: 138037-04-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzamide, N-[phenyl(trimethylsilyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-[phenyl(trimethylsilyl)methyl]-(138037-04-4)
• EPA Substance Registry System: Benzamide, N-[phenyl(trimethylsilyl)methyl]-(138037-04-4)

Safety Data

• Hazardous Substances Data: 138037-04-4(Hazardous Substances Data)

Upstream product

• 393-52-2 2-Fluorobenzoyl chloride 
• 445-29-4 o-fluoro-benzoic acid 
• 75-77-4 chloro-trimethyl-silane 
• 724-37-8 2-fluoro-N-(phenylmethyl)benzamide 

Downstream Products

• 252959-03-8 methyl N-[α-(trimethylsilyl)benzyl]benzimidate 
• 13901-70-7 dimethyl 2,5-diphenyl-1H-pyrrole-3,4-dicarboxylate 
• 19054-95-6 3,4-dimethoxycarbonyl-2,5-diphenyl-1-pyrrolidine 
• 19054-95-6 3,4-dimethoxycarbonyl-2,5-diphenyl-1-pyrrolidine 
• 111678-11-6 r-1H,c-4H,c-5H-2,4,7-triphenyl-6,8-dioxo-3,7-diazabicyclo<3.3.0>oct-2-ene 
• 111678-11-6 r-1H,t-4H,c-5H-2,4,7-triphenyl-6,8-dioxo-3,7-diazabicyclo<3.3.0>oct-2-ene 

Relevant articles and documents

Site-Selective Silylation of Aliphatic C-H Bonds Mediated by [1,5]-Hydrogen Transfer: Synthesis of α-Sila Benzamides

The first example of site-selective silylation of C(sp3)-H bonds mediated by a [1,5]-hydrogen transfer is reported. This reaction occurs selectively at the α-position of benzamides with a combination of tert-butylmagnesium chloride and a catalytic amount of 4,4′-di-tert-butylbipyridine (dtbpy) ligand and provides a facile route for the creation of biologically interesting α-sila benzamides. Late-stage functionalization of the incorporated silyl moieties facilitates the synthesis of N-formyl, cis-enamine, β-hydroxyl, amino, and pyrrole-containing derivatives.