13901-70-7Relevant articles and documents
Tandem Synthesis of Tetrasubstituted NH Pyrroles from Simple Nitriles
Kim, Hyeongsu,Xuan, Zi,Hyun Kim, Ju
supporting information, p. 3336 - 3340 (2021/09/09)
An efficient tandem route to obtain tetrasubstituted NH pyrroles in a one-pot manner has been developed, staring from simple nitriles, ethyl bromoacetates, and zinc. This reaction involves oxidative dimerization of the zinc bromide complex of β-enaminoesters using cerium ammonium nitrate (CAN) as an oxidant, affording 2,3,4,5-tetrasubstituted pyrroles in yields up to 91%.
Synthesis of Polycarbonyl Pyrroles via K2S2O8-Mediated Oxidative Cyclization of Enamines
Gao, Peng,Wang, Juan,Bai, Zi-Jing,Shen, Li,Yan, Yun-Yun,Yang, De-Suo,Fan, Ming-Jin,Guan, Zheng-Hui
supporting information, p. 6074 - 6077 (2016/12/09)
A novel K2S2O8-promoted oxidative cyclization of enamines is described. A variety of enamines having diverse functional groups and substitution patterns react well using K2S2O8 as the oxidant in the absence of catalyst. This protocol provides a very simple route for the synthesis of polycarbonyl pyrroles and has the advantages of readily available starting materials, mild reaction conditions, and a wide scope of substrates.
Synthesis of polysubstituted pyrroles via phi(OAC)2-mediated oxidative coupling of enamine esters and ketones
Wang, Jun-Yan,Liu, Su-Ping,Yu, Wei
experimental part, p. 2529 - 2533 (2010/02/28)
Enamine esters or ketones could undergo homocoupling by the action of (diacetoxyiodo)benzene in the presence of BF3OEt2, giving rise to pyrrole products. This reaction could be used to synthesize symmetric polysubstituted pyrroles. Some asymmetric polysub