1381841-95-7Relevant academic research and scientific papers
Copper-catalyzed domino synthesis of isoquinolino[2,3-a]quinazolinones
Liu, Tao,Zhu, Chongyu,Yang, Haijun,Fu, Hua
, p. 1579 - 1584 (2012/07/13)
A copper-catalyzed domino method for synthesis of isoquinolino[2,3-a] quinazolinones has been developed using readily available, substituted methyl 2-(2-haloobenzamido)benzoates and nitriles as the starting materials. The domino process comprises an Ullmann-type C-arylation, intramolecular addition of NH with CN, and nucleophilic attack of amino to ester group. The inexpensive, convenient and efficient copper-catalyzed method should provide a new and useful strategy for constructing nitrogen heterocycles. Copyright
