1381949-95-6

Basic information

• Product Name: C₂₃H₃₆N₄O₄
• CAS NO: 1381949-95-6
• Molecular Weight: 432.563
• Mol File: 1381949-95-6.mol

Chemical Properties

• CAS DataBase Reference: C₂₃H₃₆N₄O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₃₆N₄O₄(1381949-95-6)
• EPA Substance Registry System: C₂₃H₃₆N₄O₄(1381949-95-6)

Safety Data

• Hazardous Substances Data: 1381949-95-6(Hazardous Substances Data)

Upstream product

• 194726-46-0 (3R)-3-formylpiperidine-1-carboxylic acid tert-butyl ester 
• 79221-45-7 piperazine-1-carboxylic acid (4-methoxy-phenyl)-amide 
• 116574-71-1 tert-butyl (3R)-3-(hydroxymethyl)piperidine-1-carboxylate 
• 1326394-37-9 tert-butyl 4-(4-methoxyphenylcarbamoyl)piperazine-1-carboxylic acid ester 

Downstream Products

• 1381949-81-0 C₂₁H₃₂N₄O₂ 

Relevant articles and documents

The design and synthesis of novel, potent and orally bioavailable N-aryl piperazine-1-carboxamide CCR2 antagonists with very high hERG selectivity

A novel N-aryl piperazine-1-carboxamide series of human CCR2 chemokine receptor antagonists was discovered. Early analogues were potent at CCR2 but also inhibited the hERG cardiac ion channel. Structural modifications which decreased lipophilicity and basicity resulted in the identification of a sub-series with an improved margin over hERG. The pharmacological and pharmacokinetic properties of the lead compound from this series, N-(3,4-dichlorophenyl)-4-[(2R)-4-isopropylpiperazine-2-carbonyl] piperazine-1-carboxamide, are described.