138281-33-1Relevant academic research and scientific papers
Phosphoric acid bridged cobalt bis(dicarbollide) ion as a highly efficient catalyst for the organocatalytic hydrogenation of ketimines
Akiyama, Takahiko,Saito, Kodai,Janczak, Slawomir,Lesnikowski, Zbigniew J.
, p. 795 - 798 (2014)
The high-yield reduction of aromatic ketimines into amines by using a novel catalyst based on a metallacarborane structure, 8,8′-μ-phosphate[(1,2- dicarba-closo-undecaborane)-3,3′-cobalt(-1)(1′,2′-dicarba- closo-undecaborane)] acid, is described. Georg Th
Oxidative Kinetic Resolution of Acyclic Amines Based on Equilibrium Control
Akiyama, Takahiko,Ito, Yui,Miyashita, Hiromitsu,Saito, Kodai,Yamanaka, Masahiro
, (2020/04/10)
An oxidative kinetic resolution of racemic acyclic amines was developed using an imine derivative as the resolving reagent and chiral phosphoric acid as the catalyst to give enantiomers in good yields with high to excellent enantioselectivities. The key t
Secondary amine compound synthesized from alkyne and synthesis method of secondary amine compound
-
, (2018/10/19)
The invention relates to a secondary amine compound synthesized from alkyne and a synthesis method of the secondary amine compound. The specific structure of the compound is shown as the formula II inthe description. Meanwhile, the invention discloses the three-step one-pot synthesis method of the compound. According to the method, cheap and available acetenyl substituted benzene (I) is taken asa raw material. The method comprises steps as follows: step 1), fluorine-containing alcohol and water are taken as solvents and subjected to a hydration reaction under catalysis of trifluoromethanesulfonic acid, and an intermediate ketone is generated; step 2), aromatic amines are added directly to a reaction system, and imine is generated; step 3), tetrahydroxydiboron is added to the system, anda product II is obtained. No metal participates in the method, operation is simple and convenient, the raw materials are easily available, reaction conditions are mild, and yield is relatively high.
Copper acetoacetonate [Cu(acac)2]/BINAP-promoted Csp 3-N bond formation via reductive coupling of N-tosylhydrazones with anilines
Aziz, Jessy,Brion, Jean-Daniel,Hamze, Abdallah,Alami, Mouad
, p. 2417 - 2429 (2013/10/01)
We report the the copper(II) acetoacetonate [Cu(acac)2]/BINAP- catalyzed synthesis of arylamines from N-tosylhydrazones and anilines. A fine tuning of the reaction conditions was required to accomplish the cross-coupling successfully, including the ligands effect and the addition of small amounts of water. The characteristic feature of this protocol is its functional group compatibility and its chemoselectivity when various aminophenol derivatives were used. Taking into consideration the interest for this copper-reductive coupling in which no stoichiometric metal hydride reagent is employed, this can be considered as an alternative to the conventional reductive amination.
Iridium/monodentate phosphoramidite catalyzed asymmetric hydrogenation of N-aryl imines
Mrsic, Natasa,Minnaard, Adriaan J.,Feringa, Ben L.,Vries, Johannes G. de
supporting information; experimental part, p. 8358 - 8359 (2009/10/23)
(Chemical Equation Presented) Asymmetric hydrogenation of N-aryl acetophenone imines using iridium/PipPhos leads to very high enantioselectivities up to >99percent depending on the presence of electron-donating substituents in the 2-, 3-, and 5-position of the aryl ring. If the substituent is 2-methoxy, the resultant secondary amines are easily oxidatively deprotected using trichloroisocyanuric acid to give the primary amines ingood yield with full retention of enantioselectivity.
