36283-44-0Relevant articles and documents
Mixtures of chiral monodentate phosphites, phosphonites and phosphines as ligands in Rh-catalyzed hydrogenation of N-acyl enamines: Extension of the combinatorial approach
Reetz, Manfred T.,Mehler, Gerlinde,Meiswinkel, Andreas
, p. 2165 - 2167 (2004)
Mixtures of BINOL-derived monodentate phosphites and phosphonites have been reacted with Rh-salts to form three (pre)catalysts, which are in equilibrium; two homo-combinations MLaLa and MLbL b as well as the het
Platinum-encapsulated zeolitically microcapsular catalyst for one-pot dynamic kinetic resolution of phenylethylamine
Shi, Jing,Li, Xiang,Wang, Quanrui,Zhang, Yahong,Tang, Yi
, p. 87 - 94 (2012)
The platinum-encapsulated zeolitically microcapsular catalyst, associated with the immobilized Candida antartica lipase B (Novozyme435), is successfully employed in the dynamic kinetic resolution of phenylethylamine. A conversion of 80% and a selectivity of 95% are achieved, and negligible loss of activity is detected even after reaction of 5 runs. It is found that the existence of the silicalite-1 shell not only effectively prevents the deactivation of both enzyme and Pt by isolating them in different regions of reaction system, but also significantly reduces the formation of by-products on the Pt nanoparticles within the protected space of zeolitic microcapsule. Such features of zeolitic shell should further promote the designing of various catalysts for multistep reaction network.
ASYMMETRIC SYNTHESIS OF N-ACETYL-PHENYLETHYLAMINE
Davies, Stephen G.,Newton, Roger F.,Williams, Jonathan M.J.
, p. 2967 - 2970 (1989)
The chromium tricarbonyl complex of the benzaldehyde acetale derived from R,R-butane-2,3-diol undergoes completely stereoselective displacement, with retention of configuration, of the pro-R acetal oxygen on treatment with titanium tetrachloride and trimethyl aluminum: A subsequent Ritter reaction releases the RR-butane-2,3-diol intact and generates stereospeciphically after decomplexation R-N-acetyl-phenylethylamine.
Homochiral Porous Framework as a Platform for Durability Enhancement of Molecular Catalysts
Sun, Qi,Dai, Zhifeng,Meng, Xiangju,Xiao, Feng-Shou
, p. 5720 - 5726 (2017)
Self-quenching and vulnerability of active sites are major issues posed for practical applications of highly efficient chiral organometallic catalysts. Here, we demonstrate an effective strategy to address these challenges by constructing them into homoch
N-acetylation of amines in continuous-flow with acetonitrile—no need for hazardous and toxic carboxylic acid derivatives
Fül?p, Ferenc,Mándity, István M.,Orsy, Gy?rgy
, (2020/04/29)
A continuous-flow acetylation reaction was developed, applying cheap and safe reagent, acetonitrile as acetylation agent and alumina as catalyst. The method developed utilizes milder reagent than those used conventionally. The reaction was tested on various aromatic and aliphatic amines with good conversion. The catalyst showed excellent reusability and a scale-up was also carried out. Furthermore, a drug substance (paracetamol) was also synthesized with good conversion and yield.
Diaza-Crown Ether-Bridged Chiral Diphosphoramidite Ligands: Synthesis and Applications in Asymmetric Catalysis
Luo, Yier,Ouyang, Guanghui,Tang, Yuping,He, Yan-Mei,Fan, Qing-Hua
, p. 8176 - 8184 (2020/07/15)
A small library of diaza-crown ether-bridged chiral diphosphoramidite ligands was prepared. In the rhodium-catalyzed asymmetric hydrogenation and hydroformylation reactions, these ligands exhibited distinct properties in catalytic activity and/or enantioselectivity. Hydrogenated products with opposite absolute configurations could be obtained in high yields with excellent ee values by utilizing (S,S)-L1 and (S,S)-L3, respectively. Meanwhile, the addition of alkali metal cations caused variations in catalytic outcomes, showing the supramolecular tunability of these Rh/diphosphoramidite catalytic systems.