138371-45-6

Basic information

• Product Name: METHYL-(2-OXO-2-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: METHYL-(2-OXO-2-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER;tert-Butyl methyl(2-oxo-2-phenylethyl)carbamate
• CAS NO: 138371-45-6
• Molecular Formula: C₁₄H₁₉NO₃
• Molecular Weight: 249.31
• Mol File: 138371-45-6.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: METHYL-(2-OXO-2-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL-(2-OXO-2-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER(138371-45-6)
• EPA Substance Registry System: METHYL-(2-OXO-2-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER(138371-45-6)

Safety Data

• Hazardous Substances Data: 138371-45-6(Hazardous Substances Data)

Usage

General Description

Methyl-(2-oxo-2-phenyl-ethyl)-carbamic acid tert-butyl ester is a compound commonly used in the synthesis of pharmaceuticals and agrochemicals. It is a carbamate ester, which means it contains an ester group and a carbamate group. The tert-butyl ester group increases the compound's stability and makes it easier to handle in laboratory settings. METHYL-(2-OXO-2-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER is also used as a reactive intermediate in the production of various other chemicals. It has a molecular formula of C13H17NO3 and a molecular weight of 235.28 g/mol.

Upstream product

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Downstream Products

• 16735-19-6 2-amino-1-phenylpropan-1-one hydrochloride 
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• 851659-40-0 tert-butyl-3-hydroxy-2-methyl-1-oxo-1-phenylpropan-2-ylcarbamate 

Relevant articles and documents

Asymmetric Transfer Hydrogenation: Dynamic Kinetic Resolution of α-Amino Ketones

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Indium metal as a reducing agent in organic synthesis

The low first ionisation potential (5.8 eV) of indium coupled with its stability towards air and water, suggest that this metallic element should be a useful reducing agent for organic substrates. The use of indium metal for the reduction of C=N bonds in imines, the heterocyclic ring in benzo-fused nitrogen heterocycles, of oximes, nitro compounds and conjugated alkenes and the removal of 4-nitrobenzyl protecting groups is described. Thus the heterocyclic ring in quinolines, isoquinolines and quinoxalines is selectively reduced using indium metal in aqueous ethanolic ammonium chloride. Treatment of a range of aromatic nitro compounds under similar conditions results in selective reduction of the nitro groups; ester, nitrile, amide and halide substituents are unaffected. Likewise indium in aqueous ethanolic ammonium chloride is an effective method for the deprotection of 4-nitrobenzyl ethers and esters. Indium is also an effective reducing agent under non-aqueous conditions and α-oximino carbonyl compounds can be selectively reduced to the corresponding N-protected amine with indium powder, acetic acid in THF in the presence of acetic anhydride or di-tert-butyl dicarbonate. Conjugated alkenes are also reduced by indium in THF-acetic acid.