138448-19-8

Upstream product

• 138448-18-7 [R-(R*,S*)]-β-[[(1,1-Dimethylethoxy)carbonyl]-amino]-α-(2-furanyl)cyclohexanepropanol 
• 77-76-9 2,2-dimethoxy-propane 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 37736-82-6 (S)-2-tert-butoxycarbonylamino-3-cyclohexylpropionic acid 
• 115766-13-7 (S)-α-[[(1,1-dimethylethoxy)carbonyl]amino]-N-methoxy-N-methylcyclohexanepropanamide 
• 98105-42-1 (S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal 

Downstream Products

• 121533-54-8 (4S,5R)-3-tert-Butoxycarbonyl-4-cyclohexyl-methyl-2,2-dimethyloxazolidine-5-carboxylic acid 
• 131316-86-4 (4S,5S)-5-((R)-2-Butylcarbamoyl-3-methyl-butyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 141258-89-1 (4S,5S)-4-Cyclohexylmethyl-5-((E)-2-methoxycarbonyl-3-methyl-but-1-enyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 141258-89-1 (4S,5S)-4-Cyclohexylmethyl-5-((Z)-2-methoxycarbonyl-3-methyl-but-1-enyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 141258-95-9 (4S,5S)-4-Cyclohexylmethyl-5-((S)-2-methoxycarbonyl-3-methyl-butyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 141258-93-7 (4S,5S)-4-Cyclohexylmethyl-5-((R)-2-methoxycarbonyl-3-methyl-butyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 141258-90-4 (4S,5S)-5-((Z)-2-Butylcarbamoyl-3-methyl-but-1-enyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 138448-17-6 (4S-trans)-4-(cyclohexylmethyl)-5-[[(methoxy)methylamino]carbonyl]-2,2-dimethyl-3-oxazolidinecarboxylic acid, 1,1-dimethylethyl ester 
• 141258-92-6 N-Butyl-2-[1-((4S,5S)-4-cyclohexylmethyl-2-oxo-oxazolidin-5-yl)-meth-(Z)-ylidene]-3-methyl-butyramide 
• 124032-42-4 [(S)-2-Cyclohexyl-1-((S)-4-isopropyl-5-oxo-2,5-dihydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester 
• 124032-36-6 (3S,5S)-5-[(1S)-1-(t-butoxycarbonyl)amino-2-cyclohexylethyl]-3-isopropyldihydrofuran-2(3H)-one 
• 123580-22-3 [(S)-2-Cyclohexyl-1-((2S,4R)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester 
• 124032-35-5 (2S,4S,5S)-5-(t-butoxycarbonyl)amino-6-cyclohexyl-4-hydroxy-2-isopropyl-N-butylhexanamide 
• 129921-94-4 N-butyl-2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanamide 

Relevant academic research and scientific papers

Synthesis of the hydroxyethylene dipeptide isostere, (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide

A stereoselective synthesis of the hydroxyethylene dipeptide isostere, (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid-n-butyl amide from Boc-L-phenylalanine is described.

DIOL SULFONAMIDE AND SULFINYL RENIN INHIBITORS

Compounds of the formula STR1 wherein Z is SO or SO 2 possess renin inhibition activity and are useful in treating hypertension and other diseases where the reduction of the levels of circulating angiotensin II are beneficial.